Results 51 to 60 of about 1,213,044 (313)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Characterizing cognitive workload during simulated surface extravehicular activity with integrated virtual reality

Frontiers in Psychology
IntroductionHigh cognitive workload presents an important risk to crew safety during surface exploration extravehicular activity (EVA). However, it remains difficult to draw conclusions about the precise EVA task characteristics that are associated with ...
Steven R. Anderson, Crystal Kirkley, Alex J. Baughman, Caleb Cram, Eryn Andrews, Kyoung Jae Kim, Rebecca DiDomenica, Morgan Stosic, Bradley Hoffmann, Patrick Estep, Suzanne T. Bell, Karina Marshall-Goebel, Daniel M. Buckland   +12 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Street Smart or Smart Street? Theater and environmental power

, 2022
In its first part the essay reflects on an ongoing transformation in the history of power relations by commenting on a short passage from Elfriede Jelinek\u27s 2013 theater text Die Schutzbefohlenen (Charges: The suppliants).
Kirsch, Sebastian
core   +2 more sources

The Effects of Decreasing Foot Strike Angle on Lower Extremity Shock Attenuation Measured with Wearable Sensors

Sensors
Shock attenuation may be a clinically feasible method to assess changes in lower extremity joint loading induced by gait modifications, such as decreasing foot strike angle (forefoot striking).
Lucas Sarantos, David J. Zeppetelli, Cole A. Dempsey, Takashi Nagai, Caleb D. Johnson   +4 more
doaj   +1 more source

Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation

International Journal of Inflammation, 2014
Burn injuries result in the release of proinflammatory mediators causing both local and systemic inflammation. Multiple organ dysfunctions secondary to systemic inflammation after severe burn contribute to adverse outcome, with the lungs being the first ...
Si Jack Chong, Yong Chiat Wong, Jian Wu, Mui Hong Tan, Jia Lu, Shabbir M. Moochhala   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Time to First Injury After Knee Surgery in U.S. Army Soldiers: A Survival Analysis

Sports Medicine - Open
Background Knee injuries, including those requiring surgical intervention, are a leading cause of disability in U.S. Army soldiers. Previous studies investigating the risk of injury after surgery have primarily focused on civilian populations and lack ...
Benjamin G. Adams, Richard B. Westrick, Perman Gochyyev, Kathryn M. Taylor   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source