Results 71 to 80 of about 890,570 (267)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Flywheel Resistance Training for Anterior Cruciate Ligament Rehabilitation

International Journal of Strength and Conditioning
The tearing or rupturing of the anterior cruciate ligament (ACL) has become an increasingly common injury in athletes, particularly in sports that require sharp, pivoting movements and sports that have high deceleration and landing demands.
Margaret Michalak, Chloe Ryan, Alex Ehlert, John Cronin   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

THE INFLUENCE OF ENVIRONMENTAL COSTS AND CARBON PERFORMANCE ON FINANCIAL PERFORMANCE: THE MEDIATING ROLE OF ENVIRONMENTAL PERFORMANCE

International Journal of Accounting Innovation
Objective: This study investigates the intricate relationships between environmental costs, carbon performance, and financial performance within corporate frameworks. The primary objective is to elucidate how environmental performance mediates the relationship between carbon performance and financial outcomes.
Amalia Hanifah, Satriyo Bayu Aji Seto
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Effect of Environmental Performance, Environmental Costs and Environmentally Friendly Products on Financial Performance

International Journal of Environmental, Sustainability, and Social Science
This research aims to find out whether environmental performance, environmental cost and eco-friendly products influence the financial performance of manufacturing companies on the Indonesia Stock Exchange. This type of company was chosen because the company has a high level of sensitivity which is of concern to investors due to the large amount of ...
Febyanti Dwi AMANDA, Slamet WIYONO, Titik ARYATI   +2 more
openaire   +1 more source

Characterising performance of environmental models

Environmental Modelling & Software, 2013
In order to use environmental models effectively for management and decision-making, it is vital to establish an appropriate level of confidence in their performance. This paper reviews techniques available across various fields for characterising the performance of environmental models with focus on numerical, graphical and qualitative methods ...
Neil D. Bennett, Barry F. W. Croke, Giorgio Guariso, Joseph H. A. Guillaume, Serena H. Hamilton, Anthony J. Jakeman, Stefano Marsili-Libelli, Lachlan T. H. Newham, John P. Norton, Charles Perrin, Suzanne A. Pierce, Barbara J. Robson, Ralf Seppelt, Alexey A. Voinov, Brian D. Fath, Vazken Andréassian   +15 more
openaire   +6 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Effect of Lightweight Wearable Resistance on the Squat and Countermovement Jumps: Does Load Dampen the Performance-Enhancing Effect of the Stretch-Shortening Cycle?

Applied Sciences
This study investigated the effects of lightweight wearable resistance on the kinetics and kinematics of squat jumps (SJ) and countermovement jumps (CMJ) with 2%, 4%, and 6% body mass (BM). Twenty male athletes (age: 18.05 ± 0.6 years; weight: 76.4 ± 7.6
Hamish Kyne, John B. Cronin
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source