Results 61 to 70 of about 16,095,113 (285)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Navigating the missing data maze: exploring multiple imputation techniques for environmental performance index data

Environmental Research Communications
The Environmental Performance Index (EPI) is widely used to assess a country’s environmental sustainability in terms of climate, environmental health, and ecosystem health.
Muhammed Haziq Muhammed Nor, Mohd Aftar Abu Bakar, Noratiqah Mohd Ariff, Wan Hanna Melini Wan Mohtar, Bernard Kok Bang Lee   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assessment of environmental health status of Iran according to the environmental performance index report in 2018

سلامت و محیط, 2020
Background and Objective: In this study, we aimed to assess Iran’s position and trends for environmental health status among the countries of “Iran’s perspective document in 1404” according to the indicators used in Environmental Performance Index (EPI ...
Mansour Shamsipour, Homa Kashani, Masud Yunesian, Kazem Naddafi, Mohammad Sadegh Hassanvand, Reza Saeedi, Mahdi Hadi, Alireza Mesdaghinia   +7 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Environmental Sustainability in Practice

, 2017
1. Introduction: What is Environmental Sustainability?2. Sustainability Education3. Environmental Planning and Management4. Sustainable Agriculture5. Geospatial Technologies and Environmental Sustainability6.
Environmental Sustainability Research Centre
core   +1 more source

Empirical effect of environmental and food factors on population—an ANOVA-inspired nonparametric approach

Frontiers in Environmental Science
IntroductionThis study is a comprehensive investigation of the relationship between food security, environmental performance, and their interaction with change in population.MethodsIt adopts a data-driven non-parametric approach, including ANOVA-inspired
Ray-Ming Chen, Ray-Ming Chen
doaj   +1 more source

Assessing Turkey's Environmental Performance: Insights from the Environmental Performance Index (EPI)

Journal of Yaşar University
The study delves into Turkey's environmental performance using the Environmental Performance Index (EPI) data from 1995 to 2022. Using data from the Environmental Performance Index (EPI) for the years 1995 to 2022, the study explores Turkey's environmental performance.
Esra Ekinci, Murat Oturakçı
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source