Results 61 to 70 of about 314,285 (254)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Navigating the missing data maze: exploring multiple imputation techniques for environmental performance index data

Environmental Research Communications
The Environmental Performance Index (EPI) is widely used to assess a country’s environmental sustainability in terms of climate, environmental health, and ecosystem health.
Muhammed Haziq Muhammed Nor, Mohd Aftar Abu Bakar, Noratiqah Mohd Ariff, Wan Hanna Melini Wan Mohtar, Bernard Kok Bang Lee   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Do Responsible Consumption and Production and Climate Policies Influence an Individual’s Environmentally Oriented Consumption and Anti-consumption?

RAC: Revista de Administração Contemporânea
Objective: this study aims to examine whether the macro and individual contexts can alter the behavioral dynamics of environmentally oriented consumption and anti-consumption. Theoretical approach: the study emphasizes the role of the interaction between
Felipe Roberto da Silva, Felipe Gerhard
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Assessment of environmental health status of Iran according to the environmental performance index report in 2018

سلامت و محیط, 2020
Background and Objective: In this study, we aimed to assess Iran’s position and trends for environmental health status among the countries of “Iran’s perspective document in 1404” according to the indicators used in Environmental Performance Index (EPI ...
Mansour Shamsipour, Homa Kashani, Masud Yunesian, Kazem Naddafi, Mohammad Sadegh Hassanvand, Reza Saeedi, Mahdi Hadi, Alireza Mesdaghinia   +7 more
doaj  

Assessing Turkey's Environmental Performance: Insights from the Environmental Performance Index (EPI)

Journal of Yaşar University
The study delves into Turkey's environmental performance using the Environmental Performance Index (EPI) data from 1995 to 2022. Using data from the Environmental Performance Index (EPI) for the years 1995 to 2022, the study explores Turkey's environmental performance.
Esra Ekinci, Murat Oturakçı
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source