Results 211 to 220 of about 7,814,454 (347)

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang   +7 more
wiley   +1 more source

A Study of Tourist Attraction Development Policy and Environmental Conservation in the Ijen Crater Natural Park

open access: diamond, 2019
Aditya Wiralatief Sanjaya   +3 more
openalex   +2 more sources

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

open access: yesAdvanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge   +9 more
wiley   +1 more source

Analog Signal Summation for Reinforcement Learning via Simultaneous Light–Voltage Modulation in a Synaptic Device

open access: yesAdvanced Science, EarlyView.
To overcome limitations of conventional AI hardware, a light‐voltage dual‐modulating synaptic (LVDS) transistor using an IGZO/InAs quantum dot hybrid structure is proposed. LVDS transistor enables analog summation for Dueling Deep Q‐Networks by independently modulating memory via optical and electrical stimuli.
Dong Gue Roe   +10 more
wiley   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

open access: yesAdvanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao   +12 more
wiley   +1 more source

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