Results 71 to 80 of about 830,984 (300)

Office of Adjudications; Public notices

, 2011
Updated irregularly; Began in 2002?; Title from home page updated to 2007 (viewed Apr. 15, 2008).; Harvested from the web on 10/3/11Proposed decisions issued by the Office of Adjudications-- Scoping notices published in the Environmental monitor-- Final ...
Connecticut. Dept. of Environmental Protection.
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Phytoplankton Diversity and Community Stability Under Nutrient Reduction and Early-Stage Ecological Regulation in a Large Eutrophic Lake

Diversity
Many lakes worldwide, including in China’s Yangtze River Basin, face eutrophication, which reduces phytoplankton diversity and increases bloom risk.
Fen Zhang, Ruiying Yang, Haiyan Liu, Chenhao Dong, Zhan Hao, Zhaosheng Chu, Tianhao Wu   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Impact of Polyvinyl Chloride (PVC) powder ingestion on growth rate and length of Oreochromis niloticus - A Preliminary Study [PDF]

E3S Web of Conferences
Aquatic ecosystems face increasing contamination from plastic pollutants, with Polyvinyl Chloride (PVC) being one of the most prevalent. This study investigates the impact of ingested PVC powder particles on the body weight and length of O.
Sadîca Isabela, Matei Monica, Boboc Mădălina, Jawdhari Abdulhusein, Cucu George, Stegărescu Sorin, Holban E.   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

DEP home page; Connecticut Department of Connecticut Dept. of Environmental Protection

, 2008
Updated irregularly; Title from home page (publisher's Web site, viewed Jan. 10, 2011); Official website of the Connecticut Department of Environmental Protection.

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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development and validation of a green/blue UHPLC-MS/MS method for trace pharmaceutical monitoring

Scientific Reports
In response to the growing concerns regarding pharmaceutical contamination of our aquatic systems, targeted actions are being implemented to align with the recommendations of the European Commission.
Marta Koziarska, Magdalena Strzebońska, Ewa Szalińska   +2 more
doaj   +1 more source