Results 131 to 140 of about 1,228,862 (258)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Assessing food security and environmental quality under policy stringency and geopolitics using counterfactual and machine learning approaches. [PDF]

Sci Rep
Ali MI, Amin MB, Salahuddin M, Hossain MN, Oláh J.   +4 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Spatial heterogeneous relationship between environmental quality and human disturbances: a case study in Ili Valley, China. [PDF]

Sci Rep
Abulizi A, Yu T, Yerkenhazi A.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Lessons from the first U.S. school districts with real-time indoor environmental quality (IEQ) sensors in classrooms: benefits, barriers and opportunities. [PDF]

Environ Res Health
Botana Martinez MP, Fabian MP, Gunn K, Walsh KH, Scammell MK.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Environmental Quality Assessment Using Fecal Metabolomics in Waterfowl from Protected Wetlands in Southwest Spain. [PDF]

ACS ES T Water
Navarro-Fernández C, Callejón-Leblic B, Domínguez-Bustos ÁR, Molina I, Hortas F, García-Barrera T.   +5 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Does Parental Presence Influence Child Performance on an Emotional Go/No-Go Task at Age 9.5? Exploring the Role of Puberty and Early Environmental Quality. [PDF]

Dev Sci
Nolvi S, Perasto L, Juntunen P, Autere TA, Huovinen V, Luotola A, Audah HK, Karukivi M, Aatsinki AK, Karlsson H, Karlsson L, Lukkarinen M, Tottenham N, Korja R.   +13 more
europepmc   +1 more source