Results 91 to 100 of about 212,973 (309)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Maximum entropy inverse reinforcement learning for campus spatial optimization from Wi-Fi probe trajectories: a case study of Southeast University Wuxi Campus

Architectural Intelligence
With the outward expansion of university campuses toward suburban areas, the modern campus has evolved into an increasingly independent social space, providing an organizational setting in which users’ daily activities rely on diverse on-campus ...
Guangjin Wang, Ruike Huang, Xiang Li, Li Li   +3 more
doaj   +1 more source

Discours écoféministes et droit de l'environnement : chassez le naturel ?

Criminocorpus
Ecofeminist thoughts have emerged during the seventies, aiming at highlighting the joint domination on feminine gender and nature. Yet, developping at the same time, modern environmental law does not seem to have been influenced by these ideas.
Romain Gosse
doaj   +1 more source

Scientific Method, Anti-Foundationalism, and Public Decision-making [PDF]

, 1990
An examination of the legitimacy of attacks on lay assessments of environmental or other technological Risk. The case is made that rational policy requires an epistemology in which what we believe about Risk is bootstrapped onto how we should act ...
Shrader-Frechette, Kristin
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Education, Rationality and Emotion in Tessitura of Socio-Technical Networks

Revista Brasileira Multidisciplinar - ReBraM /Brazilian Multidisciplinay Journal, 2015
This work aims to reflect on the concepts of Humberto Maturana, a Chilean biologist, who rescues the crossover tension between emotion and rationality, based on the proposals of two doctoral studies in an environmental multidisciplinary program, at UERJ (
Fátima Kzam Damaceno de Lacerda, Maristela Barenco Corrêa de Mello, Fátima Teresa Braga Branquinho   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

An ethic for geography: The role of the affective domain in developing environmental awareness

Southern African Journal of Environmental Education, 1984
Geography is a subject with integral ethical and moral components. However, because of the subject's traditionally close association with scientific rationality this factor has not always been recognised.
Margaret E. Marker
doaj  

Rational Individual and Managerial Decision Model: A Critical Review of the Standard Rationality Hypothesis [PDF]

Business Ethics and Leadership
Classical economic analysis is based on the hypothesis of perfect rationality attributed to economic agents. Their behavior is considered, according to this analysis, in a narrow sense represented by Homo-oeconomicus. The latter is a calculating agent in
Miloudi Kobiyh, Adil El Amri
doaj   +1 more source