Results 121 to 130 of about 212,973 (309)

The determinants of successful partnering: a transaction cost perspective [PDF]

open access: yes, 2006
Support is emerging for the assertion that partnering can have a significant beneficial influence on project relationships and project outcomes. However, not all of the evidence bears this out: there are some examples of less-than-successful experiments ...
Greenwood, David, Yates, D. J.
core  

An Adversarial Interpretation of Information-Theoretic Bounded Rationality

open access: yes, 2014
Recently, there has been a growing interest in modeling planning with information constraints. Accordingly, an agent maximizes a regularized expected utility known as the free energy, where the regularizer is given by the information divergence from a ...
Lee, Daniel D., Ortega, Pedro A.
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Elements of Environmental Rationality

open access: yes, 2008
This article does are taken elements of the reflection of thinkers from different disciplines, especially environmentalists to build a concept of rationality environmental, such as motivating and router action. The issue is justified for two reasons: 1) economic rationality has become the only parameter for decision-making and does not allow that other
openaire   +1 more source

An Integrated Assessment approach to linking biophysical modelling and economic valuation tools [PDF]

open access: yes
Natural resource management (NRM) typically involves complex decisions that affect a variety of stakeholder values. Efficient NRM, which achieves the greatest net environmental, social and financial benefits, needs to integrate the assessment of ...
Bennett, Jeffrey W.   +2 more
core   +1 more source

Embodied Akrasia: James on Motivation and Weakness of Will [PDF]

open access: yes, 2018
This paper presents an account of akrasia, drawn from the work of William James, that sees akrasia as neither a rational failing (as with most philosophical accounts) nor a moral failing (as with early Christian accounts), but rather a necessary by ...
Bromhall, Kyle
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz   +3 more
wiley   +1 more source

Extending the Bounded Rationality Model: The Distributed Cognition Approach [PDF]

open access: yes
The way Simon, and the major part of the scholars, presented and used bounded rationality directly refers to human computational capabilities (or “brute-force”).
Bardone Emanuele, Secchi Davide
core  

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