Results 121 to 130 of about 7,449,547 (302)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Direct regulation is an efficient approach to industrial environmental improvement: empirical evidence and perceptions from chemical manufacturers in Ireland and Italy. [PDF]
Industrial production is a major source of global pollution, and it is widely recognised that regulation is required to reduce this pollution for the benefit of society.
David Styles +2 more
core
A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
EMBO ReportsDecitabine (DAC), a well-recognized DNA hypomethylating agent, has been applied to treat acute myeloid leukemia. However, clinic investigations revealed that DNA methylation reduction does not correlate with a clinical response, and relapse is prevalent.
Pinqi Zhang +8 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Environmental regulation and the location of polluting industries [PDF]
Does international tax competition in the environmental field lead to undesirably low levels of environmental regulation and to unacceptable disruptions of environmental quality?
Rauscher, Michael
core
Environmental regulation by private contest [PDF]
, 1995 It is widely expected that the recent trend (in the USA, EU and elsewhere) towards an increased role for private agents and agencies in the formulation and enforcement of environmental regulation will continue.
Heyes, Anthony G.
core
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Environmental regulation and international trade patterns for agro-industrial under a South-North Perspective [PDF]
This paper aims at examining the relation between the international trade and the environment, particularly focused on sensitive agribusiness sectors. It consists on an empirical test to the conflicting positions supported by economists, some following ...
Feix, Rodrigo Daniel +2 more
core
Nature CommunicationsClimate change is altering vegetation patterns on the Qinghai-Tibet Plateau, where diverse Köppen climate zones reveal complex ecological responses. Here, we advance from a categorical view of climate, represented by Köppen-Geiger classifications, to a ...
Yanlong Guan +8 more
doaj +1 more source