Results 41 to 50 of about 203,753 (249)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Impacts of cyclone and flood on crop and fish production in disaster prone coastal Bhola district of Bangladesh

International Journal of Agricultural Research, Innovation and Technology, 2020
This study assessed the impact of climate change induced disaster on crops and fisheries production at Bhola Sadar and Monpura upazila of Bhola district, Bangladesh during January to June 2018. The study was gathered primary data from primary observation
MS Islam, MR Jamil, MN Chowdhury, MH Kabir, RH Rimi   +4 more
doaj   +1 more source

Does the punishment fit the crime? Consequences and diagnosis of misspecified detection functions in Bayesian spatial capture–recapture modeling

Ecology and Evolution, 2022
Spatial capture–recapture (SCR) analysis is now used routinely to inform wildlife management and conservation decisions. It is therefore imperative that we understand the implications of and can diagnose common SCR model misspecifications, as flawed ...
Soumen Dey, Richard Bischof, Pierre P. A. Dupont, Cyril Milleret   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Effectiveness of Sustainable Land Management Practices on Soil Loss Reduction in Selected Watersheds From the Upper Source of the River Nile, Ethiopia

Applied and Environmental Soil Science
In the highland areas of Ethiopia, farming communities are struggling with severe soil erosion, which is putting significant strain on ecosystems and food production capabilities.
Wondimagegn Mengist, Gebeyehu Abebe, Hamere Yohannes, Abreham Berta Aneseyee, Sileshi Degefa, Meron Tekalign, Teshome Soromessa, Mekuria Argaw, Seyoum Leta, Ahmed Hussen, Eyasu Elias   +10 more
doaj   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Effects of land uses and slope gradients on soil physicochemical properties in Woynwha watershed, Northwest Ethiopia

Agrosystems, Geosciences & Environment
Soil quality degradation has become a major problem that results in low agricultural productivity and increasing food insecurity in sub‐Saharan Africa. Improving our understanding of how different land uses and slope positions affect soil properties is ...
Workineh Ejigu Mesfin, Degitu Wassie, Temesgen Gashaw Tarkegn, Yihenew G. Selassie, Eyayu Molla   +4 more
doaj   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Nilai Ekonomi Jasa Penyerbukan pada Perkebunan Kopi Robusta

Jurnal Ilmu Lingkungan
Lebah berkontribusi terhadap pasokan makanan global sebagai penyerbukan berbagai tanaman, termasuk hortikultura, tanaman pangan, dan lainnya. Keberadaan lebah dan fungsinya sebagai penyerbuk menghadapi banyak tantangan seperti perubahan iklim dan teknik ...
Nuraulia Asyifa, Pini Wijayanti, Ahyar Ismail   +2 more
doaj   +1 more source

Clustering simulated snow profiles to form avalanche forecast regions [PDF]

Geoscientific Model Development
This study presents a statistical clustering method that allows avalanche forecasters to explore patterns in simulated snow profiles. The method uses fuzzy analysis clustering to group small regions into larger forecast regions by considering snow ...
S. Horton, S. Horton, F. Herla, P. Haegeli   +3 more
doaj   +1 more source