Results 121 to 130 of about 6,525,124 (309)

United States Environmental Protection Agency

, 2019
The mission of United States Environmental Protection Agency (EPA) is to protect human health and the environment and to ensure that Americans have clean air, land and water, as well as to promote national efforts to reduce environmental risks are based ...
United States Environmental Protection Agency
core   +1 more source

The determination of present and possible environmental risks in solid waste dumping site, Tunceli, Turkey.

, 2018
Leachate was a major cause of high risk classification. This landfill was set as one with highest possible risk classification due to high vulnerability of private water wells to contamination from leachate flows.
Deniz Demirbilek, Gökhan Önder Ergüven, Nuran Cıkcıkoğlu Yıldırım, Dilan Tulpar, Yildirim, N.C. Demirbilek, D. Erguven, G.O. Kayar, R. Basaran,S. Tulpar D., Rahime Kayar, Şenay Başaran   +6 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Overreaction to Fearsome Risks [PDF]

Fearsome risks are those that stimulate strong emotional responses. Such risks, which usually involve high consequences, tend to have low probabilities, since life today is no longer nasty, brutish and short.
Zeckhauser, Richard
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Gut-lung axis: a novel mechanism involving microbiota dysbiosis-coordinated PLA2-TRPV1 neuroimmune crosstalk in nanoplastic-induced asthma exacerbation

Environment International
This study, based on an OVA-sensitized mouse model, systematically elucidates the molecular mechanisms through which 20 nm polystyrene nanoplastics (PS-NPs) exacerbate asthma.
Xin Zeng, Chuhao He, Jitong Li, Qing Feng, Zhenjie Lu, Long Li, Yongkang Qiao, Wei Han, Faming Wang, Mingqing Chen, Chan Lu, Rong She, Yang Wu, Yanling Sun, Xu Yang, Ping Ma, Surui Lu   +16 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Environmental Sustainability in Practice

, 2017
1. Introduction: What is Environmental Sustainability?2. Sustainability Education3. Environmental Planning and Management4. Sustainable Agriculture5. Geospatial Technologies and Environmental Sustainability6.
Environmental Sustainability Research Centre
core   +1 more source

Extraction of valuable metals from acid mine drainage by an electrochemically activated limestone system

Nature Communications
Acid mine drainage (AMD) contains toxic yet valuable heavy metals. Conventional chemical neutralization using hydrated lime is highly efficient in mitigating heavy metal pollution, yet it generates hazardous solid wastes and is inefficient in recovering ...
Weiquan Li, Junqi Wang, Zhengshuo Zhan, Jiayu Luo, Dongmei Zhou, Yang Lei   +5 more
doaj   +1 more source

Environmental risks insurance

, 2011
This thesis deals with the insurance of environmental risks. Introduction to the whole issue is environmental policy, which is a tool for environmental insurance. The second part is devoted to explain the concepts of risk and environmental risk.
Hübnerová, Petra
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