Results 71 to 80 of about 6,525,124 (309)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Do increasing prices affect food deprivation in the European Union?

Spanish Journal of Agricultural Research, 2018
The rise of prices of agricultural commodities in global markets during 2007-2012 was followed by increased consumer food prices around the world. More expensive food may have an impact on consumer food access and thus on their welfare, not only in ...
Sol García-Germán, Isabel Bardají, Alberto Garrido   +2 more
doaj   +1 more source

The Generational Divide in Support for Environmental Policies: European Evidence [PDF]

This article examines age variations in support for environmental protection policies that affect climate change using a sample of over 14,000 respondents to a 1999 Eurobarometer survey.
Hersch, Joni, Viscusi, W. Kip
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Farmers' perception on risks in fruits and vegetables production: an empirical study of Uttar Pradesh [PDF]

The perceptions of farmers about risks in production of fruits and vegetables have been analysed using structured survey method. The study is based on the survey of a total of 634 farmers, comprising 188 fruit farmers and 446 vegetable farmers, covering ...
Kapoor, Sanjeev, Ali, Jabir
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Real-time electrical monitoring of enzymatic catalytic dynamics at the single-molecule level

Nature Communications
Monitoring enzyme structural dynamics is essential for elucidating catalytic mechanisms, yet transient conformational fluctuations on microsecond-to-millisecond timescales remain challenging to resolve with conventional techniques.
Zhimin Fan, Zusen Chen, Zhengwen Gong, Sanjun Shi, Mingdi Xu, Xiaonan Feng, Yulu Liu, Ya Hu, Xiaoduo Chen, Guomao Zheng, Bintian Zhang   +10 more
doaj   +1 more source

Integrated wildfire susceptibility and hazard mapping: A data-driven approach for Mediterranean regions using the Garrotxa (Catalonia, Spain) as a case study

Climate Services
Wildfires represent a growing threat to Mediterranean landscapes, where socio-ecological factors, land use dynamics and climate variability converge to increase fire risk.
Júlia Sánchez-Martínez, Arnau Lagresa-Gardella, Marta López-Saavedra, Iris Schneider-Pérez, Xavier Arnau-Sarabia, Marc Martínez-Sepúlveda, Mireia Jiménez-Llobet, Joan Martí   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source