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Environmental exposures and RNA N6-Methyladenosine modified long Non-Coding RNAs
Critical Reviews in Toxicology, 2020Recent advances in the field of RNA modifications and long non-coding RNAs (lncRNAs) have provided substantial evidence on important biological functions. LncRNAs are defined as longer than 200 nucleotides which are not translated into proteins. The term "epitranscriptome" refers to all modifications in RNA types.
Akin Cayir
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Science of The Total Environment, 2021
Traditional environmental biomonitoring approaches have limitations in terms of species detectability and their capacity to account for spatial and temporal variation. Furthermore, as invasive techniques they can be harmful to individual organisms, populations and habitats.
Heather D, Veilleux +2 more
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Traditional environmental biomonitoring approaches have limitations in terms of species detectability and their capacity to account for spatial and temporal variation. Furthermore, as invasive techniques they can be harmful to individual organisms, populations and habitats.
Heather D, Veilleux +2 more
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Can Environmental RNA Revolutionize Biodiversity Science?
Trends in Ecology and Evolution, 2019The use of environmental RNA (eRNA) for species identification remains unexplored due to the observation that in vitro RNA is much less stable than DNA. However, recent lines of evidence suggest that RNA may be abundantly excreted by organisms and sufficiently persistent in the environment to reconstruct community composition and gene expression.
Melania E Cristescu
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Environmental RNA interference
Trends in Genetics, 2008The discovery of RNA interference (RNAi), the process of sequence-specific gene silencing initiated by double-stranded RNA (dsRNA), has broadened our understanding of gene regulation and has revolutionized methods for genetic analysis. A remarkable property of RNAi in the nematode Caenorhabditis elegans and in some other multicellular organisms is its ...
Jennifer S, Whangbo, Craig P, Hunter
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Mutational RNA signatures in environmentally-induced lung adenocarcinoma
11.01 - Lung cancer, 2021Introduction: Lung adenocarcinoma (LUAD) is the most frequent lung cancer in non-smokers. Although carcinogens other than smoking (i.e., radiation) likely cause LUAD, their molecular imprints are obscure. Objectives: To define the molecular imprints of smoking, its carcinogens, and radiation in LUAD RNA.
Georgia A. Giotopoulou +7 more
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RNA 5-Methylcytosine Controls Plant Development and Environmental Adaptation
Trends in Plant Science, 2020Despite increasing understanding of 5-methylcytosine (m5C) on RNAs in mammals, the function of m5C in plants remains obscure. A dynamic function of m5C in plant development and stress adaptation had been suggested, and Tang et al. have now uncovered a role for RNA m5C methyltransferase in rice adaptation to high temperature.
Pingxian, Zhang +2 more
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RNA metabarcoding helps reveal zooplankton community response to environmental stressors
Environmental Pollution, 2022DNA metabarcoding can provide a high-throughput and rapid method for characterizing responses of communities to environmental stressors. However, within bulk samples, DNA metabarcoding hardly distinguishes live from the dead organisms. Here, both DNA and RNA metabarcoding were applied and compared in experimental freshwater mesocosms conducted for ...
Phillip J. Ankley +7 more
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Environmental Shaping of Ribosomal RNA Nucleotide Composition
Microbial Ecology, 2008Ribosomal RNA (rRNA) is one of the most important macromolecules in the cell. It is well established that high-temperature environmental conditions destabilize rRNA, leading to a selection for G+C-rich stabilizing structures. Our knowledge about the nucleotide composition effect of other environmental conditions, however, is limited.
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RNA silencing: Mechanism, biology and responses to environmental stress
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2011Much early work on environmental stress, including ionizing radiation and environmental toxins, emphasised their action on DNA and subsequent mutagenesis in long term effects including germ cell mutagenesis, carcinogenesis and trans-generational effect.
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