Results 51 to 60 of about 3,297,912 (305)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Evaluation of Dust Concentrations in an Iranian Portland Cement Industry [PDF]
Long term exposure to high levels of cement dust is one of the most important environmental risk factor in cement industries that adversely affect employees' respiratory system.
حضرتی, صادق +1 more
core
Reference intervals for urinary cotinine levels and the influence of sampling time and other predictors on its excretion among italian schoolchildren [PDF]
, 2018 (1) Background: Environmental Tobacco Smoke (ETS) exposure remains a public health problem worldwide. The aims are to establish urinary (u-) cotinine reference values for healthy Italian children, to evaluate the role of the sampling time and of other ...
Andreoli, Roberta +5 more
core +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Technology, culture and location in a recent New Zealand sonic art project [PDF]
, 2008 The HIEMPA (Hybrid Instruments from Electroacoustic Manipulation And Models of Pütorino and Aquascape) project combined a team of people with technical, artistic, environmental and cultural expertise toward the artistic outcome of extending the New ...
Whalley, Ian
core +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Measuring micro-organism gas production [PDF]
, 1973 Transducer, which senses pressure buildup, is easy to assemble and use, and rate of gas produced can be measured automatically and accurately. Method can be used in research, in clinical laboratories, and for environmental pollution studies because of ...
Mills, S. M. +2 more
core +1 more source
Evaluating the cooling rate of hot mix asphalt in tropical climate [PDF]
, 2016 This paper aims to investigate the environmental effect on cooling rate and to determine the appropriate time available for compaction (TAC) using laboratory tests.
Abdul Hassan, Norhidayah +5 more
core +1 more source