Results 111 to 120 of about 1,521,759 (254)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The impact of plastic during the COVID-19 pandemic: The point of view of the environmental science literature. [PDF]

Mater Today Proc, 2023
de Sousa FDB.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Publishing a sound paper of environmental science and ecological technology: Some experiences and tips for young researchers. [PDF]

Environ Sci Ecotechnol, 2023
Ho SH, Ren NQ.
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Enabling FAIR data in Earth and environmental science with community-centric (meta)data reporting formats. [PDF]

Sci Data, 2022
Crystal-Ornelas R, Varadharajan C, O'Ryan D, Beilsmith K, Bond-Lamberty B, Boye K, Burrus M, Cholia S, Christianson DS, Crow M, Damerow J, Ely KS, Goldman AE, Heinz SL, Hendrix VC, Kakalia Z, Mathes K, O'Brien F, Pennington SC, Robles E, Rogers A, Simmonds M, Velliquette T, Weisenhorn P, Welch JN, Whitenack K, Agarwal DA.   +26 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Online Community and Citizen Science supports environmental science learning by young people. [PDF]

Comput Educ, 2022
Herodotou C, Ismail N, Aristeidou M, Miller G, Lahnstein AIB, Khanaposhtani MG, Robinson LD, Ballard HL.   +7 more
europepmc   +1 more source

The science of environmental influence [PDF]

Paediatrics & Child Health, 2003
openaire   +2 more sources