Results 41 to 50 of about 17,235,601 (296)

Suppression of Environmental Science

American Journal of Law & Medicine, 2004
There is a long history of attacks on scientists. During the Inquisition, the Roman Catholic Church charged Galileo with heresy and, after imprisonment and threats of torture, forced him to renounce his theory that the sun, not the earth, was the center of the universe.
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

An Industrial Internet-of-Things (IIoT) Open Architecture for Information and Decision Support Systems in Scientific Field Campaigns

Sensors
Information and decision support systems are essential to conducting scientific field campaigns in the atmospheric sciences. However, their development is costly and time-consuming since each field campaign has its own research goals, which result in ...
Yehuda Arav, Ziv Klausner, Hadas David-Sarrousi, Gadi Eidelheit, Eyal Fattal   +4 more
doaj   +1 more source

Enhancing Biological Treatment Efficiency: A Review of Activated Sludge Models in Waste Water Treatment Plants (WWTPs) [PDF]

E3S Web of Conferences
Activated Sludge Models (ASMs) are effective tools for enhancing wastewater treatment plants. as an important aspect of engineering and technology in the water sector, They replicate the biological and chemical processes involved in organic carbon ...
Besbou Oualid, Khamar Mohamed, Cherkaoui Essediya, Amouch Said   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Protocol for detecting eDNA in ecological rare fish using RPA-CRISPR-Cas12a technology

STAR Protocols
Summary: The recombinase polymerase amplification (RPA)-CRISPR-Cas12a-FQ system enables sensitive detection of environmental DNA (eDNA) in rare fish species.
Xing-Yi Wei, Yang Pei, Li Liu, Péter Hamar, De-Sheng Pei   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Protocol for sampling multidrug-resistant bacteria using artificial plastic substrates in aquatic ecosystems

STAR Protocols
Summary: Artificial plastic substrates (APSs) consist of four plastic polymers that work as traps for pathogenic bacteria and facilitate their sampling and detection.
Ifra Ferheen, Roberto Spurio, Stefania Marchggiani   +2 more
doaj   +1 more source