Results 121 to 130 of about 892,772 (310)

The diversity and evolution of ecological and environmental citizen science

PLOS ONE, 2017
Citizen science-the involvement of volunteers in data collection, analysis and interpretation-simultaneously supports research and public engagement with science, and its profile is rapidly rising. Citizen science represents a diverse range of approaches, but until now this diversity has not been quantitatively explored.
Pocock, Michael J.O., Tweddle, John C., Savage, Joanna, Robinson, Lucy D., Roy, Helen E.   +4 more
openaire   +6 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

How perilous are broad-scale correlations with environmental variables? [PDF]

, 2020
Many studies correlate geographic variation of biotic variables (e.g., species ranges, species richness, etc.) with variation in environmental variables (climate, topography, history).
Boucher-Lalonde, Véronique, Currie, David J., Pétrin, Cloé   +2 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Rarity of monodominance in hyperdiverse Amazonian forests. [PDF]

, 2019
Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence
Alonso, Alfonso, Amaral, Iêda Leão, Andrade, Ana, Araujo-Murakami, Alejandro, Arboleda, Nicolás Castaño, Arroyo, Luzmila, Assis, Rafael L, Aymard C, Gerardo A, Baraloto, Chris, Brienen, Roel, Bánki, Olaf S, Camargo, José Luís, Carim, Marcelo de Jesus Veiga, Carvalho, Fernanda Antunes, Castellanos, Hernán, Castilho, Carolina V, Casula, Katia Regina, Cintra, Bruno Barçante Ladvocat, Coelho, Luiz de Souza, Comiskey, James A, Costa, Flávia RC, Cárdenas López, Dairon, Dallmeier, Francisco, Damasco, Gabriel, de Aguiar, Daniel Praia Portela, de Medeiros, Marcelo Brilhante, de Sousa Farias, Emanuelle, de Souza, Fernanda Coelho, de Toledo, José Julio, Demarchi, Layon O, do Amaral, Dário Dantas, Draper, Freddie, Duivenvoorden, Joost F, Duque, Alvaro, Dávila, Nállarett, Engel, Julien, Feeley, Kenneth J, Feitosa, Yuri Oliveira, Feldpausch, Ted R, Ferreira, Leandro Valle, Filho, Diogenes de Andrade Lima, García-Villacorta, Roosevelt, Gomes, Vitor HF, Groeneveld, Jürgen, Guevara, Juan Ernesto, Guimarães, José Renan da Silva, Helal, Nora, Henkel, Terry W, Honorio Coronado, Euridice N, Huth, Andreas, Irume, Mariana Victória, Killeen, Timothy J, Laurance, Susan GW, Laurance, William F, Lima de Queiroz, Helder, Lloyd, Jon, Lopes, Aline, Lopes, Maria Aparecida, Lozada, José Rafael, Luize, Bruno Garcia, Magalhães, José Leonardo Lima, Magnusson, William E, Manzatto, Angelo Gilberto, Marimon, Beatriz S, Marimon-Junior, Ben Hur, Martins, Maria Pires, Matos, Francisca Dionízia de Almeida, Mendonça Nascimento, Henrique Eduardo, Mendoza, Abel Monteagudo, Mogollón, Hugo F, Molino, Jean-François, Montero, Juan Carlos, Moraes de Leão Novo, Evlyn Márcia, Mostacedo, Bonifacio, Neill, David, Núñez Vargas, Percy, Petronelli, Pascal, Phillips, Oliver L, Piedade, Maria Teresa Fernandez, Pitman, Nigel CA, Quaresma, Adriano, Ramos, José Ferreira, Reis, Neidiane Farias Costa, Revilla, Juan David Cardenas, Rincón, Lorena M, Sabatier, Daniel, Salomão, Rafael P, Schietti, Juliana, Schöngart, Jochen, Silva, Thiago Sanna Freire, Simon, Marcelo Fragomeni, Sousa, Thaiane R, Stevenson, Pablo R, Ter Steege, Hans, Terborgh, John, Vasquez, Rodolfo, Venticinque, Eduardo Martins, Vicentini, Alberto, Vieira, Ima Célia Guimarães, Wittmann, Florian   +99 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Sustainability, emergence and the graduate attribute of global citizenship [PDF]

, 2013
Universities have an another valuable role in enabling sustainability besides their research capacity. We are interested in their role as risk taking institutions, because we see risk as a pre-condition for sustainability.
Bender, Helena, Judith, Kate
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source