Results 201 to 210 of about 892,772 (310)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Retrospective isotope monitoring reveals spatial and temporal effects of anthropogenic pressures on the trophic ecology of European wildcats (Felis silvestris) in Germany. [PDF]

PLoS One
Baumann C, Streif S, Akarsu AS, Nowak C, Drucker DG.   +4 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Freshwater Snails at the Biodiversity-Climate-Health Nexus: A Call to Recognize Neglected Models for Eco-Evolutionary and One Health Research. [PDF]

Ecol Evol
Chapuis E.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Environmental conditions shape the global distribution of ant societies. [PDF]

Proc Natl Acad Sci U S A
Pérochon E, Guénard B, Gippet JMW, Klaftenberger T, Ollier S, Bertelsmeier C.   +5 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Regional variations in the diet of the South Polar Skua (Stercorarius maccormicki) in the Ross Sea region, Antarctica. [PDF]

PLoS One
Kim J, Kim Y, Kim JU, Oh Y, Kim JH.
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A global biodiversity use data infrastructure acknowledging indigenous and local knowledge. [PDF]

NPJ Biodivers
Pankararu CJ, Teixidor-Toneu I, Odonne G, Asante F, Bandeira SO, Barrera-Bello ÁM, Benitez-Capistros FJ, Dahdouh-Guebas F, Dalcin E, Dennehy-Carr ZH, Diallo K, Drouet-Cruz HT, Fonseca-Kruel VS, Gallois S, Gnansounou SC, Hamza AJ, Hugé J, Jordan FM, Kalle R, Khan NI, Kuijper I, Levis C, Lima AS, Mattalia G, Milliken W, Munga CN, Narchi NE, Ngeve MN, Ofori SA, Phartyal SS, Peroni N, Pironon S, Polanía J, Prakofjewa J, Silva MT, Sõukand R, Thomas MB, Ulian T, Uprety Y, Vandebroek I, Ximenes AC, Zank S, Hanazaki N.   +42 more
europepmc   +1 more source