Results 91 to 100 of about 217,008 (251)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Green waste biochar and plant growth-promoting bacteria enhance tomato growth under combined nutrient deficiency and salinity stress

Scientific Reports
This study characterized a green-waste-derived biochar from date palms and ghaf trees and investigated its potential as a soil amendment with halotolerant Bacillus spp.
Soumaya Tounsi-Hammami, Munawwar Ali Khan, Mahra Alqemzi, Salama Ali Almehairi, Aneesa Rasheed Anwar   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Pathways to open market sustainability at Mtapa Open Market in Gweru, Zimbabwe

Discover Sustainability
Open markets in developing countries face persistent sustainability challenges, including inadequate infrastructure, poor sanitation, and exposure to environmental stressors.
Juliet Chidochashe Runokunda, Mark Makomborero Matsa, Beauty Dzawanda   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

ANXIOUS MINDS OR BROKEN HEARTS: SEX SPECIFIC CONSEQUENCES OF VICARIOUS SOCIAL STRESS IN RATS

IBRO Neuroscience Reports, 2023
Margherita Barbetti, Rocchina Vilella, Monia Savi, Andrea Sgoifo, Luca Carnevali   +4 more
doaj   +1 more source

Map analysis of soil erodibility rates and gully erosion sites in Anambra State, South Eastern Nigeria

Open Geosciences
Nigeria faces severe food security challenges caused by insecurity, flooding, and soil erosion. In the north, insecurity has prevented many farmers from accessing their farms, while in the south, especially in Anambra State, gully erosion is causing a ...
Ayadiuno Romanus Udegbunam, Ndulue Dominic Chukwuka, Ezeh Christopher Uche   +2 more
doaj   +1 more source