Results 121 to 130 of about 1,765,074 (271)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

The Socioeconomic Determinants of Individual Environmental Concern: Evidence from Shanghai Data [PDF]

open access: yes
This study examines the influence of socioeconomic characteristics on eleven measures of environmental concern by applying a pooled sample of 1200 individuals in Shanghai, China.
Junyi Shen, Tatsuyoshi Saijo
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Soil quality and microbial diversity across organic and conventional coffee in central Western Ghats India

open access: yesScientific Reports
The green revolution, characterized by intensive farming practices and synthetic agrochemicals, has been associated with concerns about ecological balance and soil health.
V. M. Apoorva Angadi   +9 more
doaj   +1 more source

Review of Fire Tests on Seats for Passenger Coaches and the Materials Used in Them

open access: yesFire
This study shows how the fire regulations for railway seats used in international traffic have changed over the last 30 years. In the past, a paper cushion was used as a flame source, and today, a 15 kW burner is used; consequently, the requirements have
Dieter Hohenwarter
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Third National report on human exposure to environmental chemicals [PDF]

open access: yes
The National Report on Human Exposure to Environmental Chemicals provides an ongoing assessment of the U.S. population\u2019s exposure to environmental chemicals using biologic monitoring (biomonitoring).

core  

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