Results 211 to 220 of about 819,369 (267)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The influence of climatic and environmental variables on sunflower planting season suitability in Tanzania. [PDF]

Sci Rep
Beteri J, Lyimo JG, Msinde JV.
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

A matter of scale: Identifying the best spatial and temporal scale of environmental variables to model the distribution of a small cetacean. [PDF]

Ecol Evol
Goh T, Jessopp M, Rogan E, Pirotta E.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Optimizing predictions of environmental variables and species distributions on tidal flats by combining Sentinel-2 images and their deep-learning features with OBIA. [PDF]

Int J Remote Sens
Madhuanand L, Philippart CJM, Nijland W, de Jong SM, Bijleveld AI, Addink EA.   +5 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Interactions between soil and other environmental variables modulate forest expansion and ecotone dynamics in humid savannas of Central Africa. [PDF]

Proc Biol Sci
Sagang LBT, Tcheferi I, Ploton P, Libalah M, Simo-Droissart M, Sirri N, Dauby G, Ngansop E, Bissek JP, Kamdem N, Mofack GII, Zebaze D, Leblanc H, Djonko F, Sonké B, Barbier N, Couteron P.   +16 more
europepmc   +1 more source

The Role of Snow-Related Environmental Variables in Plant Conservation Plans in the Mediterranean Mountains. [PDF]

Plants (Basel)
Algarra JA, Cariñanos P, Ramos-Lorente MM.   +2 more
europepmc   +1 more source

Temporal-Spatial Fluctuations of a Phytoplankton Community and Their Association with Environmental Variables Based on Classification and Regression Tree in a Shallow Temperate Mountain River. [PDF]

Microorganisms
Tian W, Wang Z, Kong H, Tian Y, Huang T.
europepmc   +1 more source