Results 51 to 60 of about 32,912 (254)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The impact of knowledge, attitude, consumption values and destination image on tourists’ responsible environmental behaviour intention [PDF]
Management Science Letters, 2019 The tourism sector has developed over the years as one of the main contributors to the nation’s socio-economy. However, tourism has also said to be the cause of the depletion of the natural environment especially the marine ecosystem due to the ...
Siti Intan Nurdiana Wong Abdullah +3 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The Effects of Demographic Variables on Students' Responsible Environmental Behaviors
Procedia - Social and Behavioral Sciences, 2012 AbstractThe aim of the study was to investigate the effects of university students’ background variables (gender, age, grade and natu re experience) on their responsible environmental behaviors. A total number of 307 students (134 females, 173 males) enrolled in various departments of Akdeniz University constituted the sample of the study.
Erdogan, Mehmet +4 more
openaire +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Responsible Behavior and Environmental Protection – in Case of Football Clubs
Applied Studies in Agribusiness and Commerce, 2019 There has been a hotspot in sports industry these days that is becoming more and more wide-spread in sports organizations and among managers, namely CSR, that is corporate social responsibility. In the life of geographical regions, towns or villages, professional football clubs play a crucial role.
Kinga Ráthonyi-Ódor +2 more
openaire +3 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Learning from conceptual models – a study of the emergence of cooperation towards resource protection in a social–ecological system [PDF]
Geoscientific Model DevelopmentEngaging ecological resource users in intervention to protect resources is challenging for governments due to the self-interest of users and uncertainty about intervention consequences.
S. Harati-Asl +2 more
doaj +1 more source