Results 141 to 150 of about 11,563,248 (344)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Conserveries Mémorielles, 2014 This article uses the example of visual devices at the Shanghai World Expo in 2010 in order to develop a reflection on the place of screens in both the fabric of artificial environments, a phenomenon characteristic of world’s fairs since the 19th Century,
Tatjana Barazon, Van Troi Tran
doaj
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Editorial: Evolvability, Environments, Embodiment & Emergence in Robotics
Frontiers in Robotics and AI, 2018 John H. Long +5 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
SPATIAL-TENPORAL CHARACTERISTICS OF INNOVATIVE DEVELOPMENT INSTITUTIONS
Вестник университета, 2019 Spatial and temporal characteristics of the institutions in general, and innovative development in particular are determined primarily by the research objectives, which correspond to different interpretations of the institutions as objects, environments,
B. Yerznkyan
doaj
Undergraduates’ Perceptions of Ideal Learning Environments
, 2007 Four hundred and fifty three undergraduate students were surveyed at one CCCU institution regarding perceptions of what “exists” and what they “value” related to university pedagogy, learning activities, assessments, and learning relationships ...
Hetzel, June, Walters, Keith
core
Environment — Geography — Environment [PDF]
Environmental Conservation, 1988 openaire +1 more source