Results 121 to 130 of about 691,475 (266)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Enzymatic activity screening in marine bacteria exposed to oxo-polyethylene in artificial marine microcosms. [PDF]

BMC Res Notes
Tan WA, Felicia F, Lestari LB, Yulandi A.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Screening and identification of a cellulase-producing strain and exploration of enzyme production process

Siliao yanjiu
The experiment aimed to screen high-yield cellulase strains and optimize the enzyme production process and enzymatic hydrolysis conditions. Through microbial screening techniques, a strain of Bacillus subtilis X-1 was isolated.
WANG Fengqing, FAN Kai, ZHENG Jia, CHEN Yanmei, XIAO Chunxia, CHEN Qi, GUO Yidong, LI Zhongxuan   +7 more
doaj  

Integrated Analysis of Polyphenol Oxidase Gene Expression and Enzymatic Activity in Purple-Fleshed Potatoes. [PDF]

Plants (Basel)
Mestanza M, Rituay P, Hernández-Amasifuen AD, Eriksson D, Del Rio AH, Condori-Apfata JA, Guerrero-Abad JC.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Molecular basis of trypsin's autolysis resistance acetylation for sustained enzymatic activity. [PDF]

Food Chem X
Qu X, Liu T, Xu Y, Wang C, Zheng X, Zhang Y, Cao P, Chen Q.   +7 more
europepmc   +1 more source

Enzymatic Activity of Polyalanyl Ribonuclease

Journal of Biological Chemistry, 1963
D, WELLNER, H L, SILMAN, M, SELA
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Neuron-specific enolase enzymatic activity as a biomarker to discriminate neurologic and orthopedic gait abnormalities in dogs. [PDF]

J Vet Intern Med
Huynh A, Byron MJ, Lenfest MI, Mukhtarov F, Yasmin R, Cohen R, Rishniw M, Travis AJ, Merbl Y.   +8 more
europepmc   +1 more source