Results 151 to 160 of about 6,659,593 (302)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

DNA-Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity. [PDF]

Small
Elnaggar M, Heuer-Jungemann A.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Applications of (+) Usnic Acid Modulate Antioxidant Enzymatic Activity in Strawberry Plants. [PDF]

Molecules
Castro-Rosalez L, Juárez-Maldonado A, Benavides-Mendoza A, González-Morales S, García-León E, Pérez-Labrada F.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Screening and identification of a cellulase-producing strain and exploration of enzyme production process

Siliao yanjiu
The experiment aimed to screen high-yield cellulase strains and optimize the enzyme production process and enzymatic hydrolysis conditions. Through microbial screening techniques, a strain of Bacillus subtilis X-1 was isolated.
WANG Fengqing, FAN Kai, ZHENG Jia, CHEN Yanmei, XIAO Chunxia, CHEN Qi, GUO Yidong, LI Zhongxuan   +7 more
doaj  

Influence of adrenomedullin on the enzymatic activity of dipeptidyl peptidase 3 <i>in vitro</i>. [PDF]

J Enzyme Inhib Med Chem
Nissen R, Yourdkhani A, Hollerbach ML, Seewald K, Santos K, Struck J, Bergmann A.   +6 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Chemical-based enzymatic activity of SOD1 variants.

Chemical-based enzymatic activity of SOD1 variants.
Md Amin Hossain (10170815), David E. Verrill (5720243), Sunanda Kannapadi (17873801), Durgalakshmi Sivasankar (10170824), Lee Makowski (591057), Dagmar Ringe (15574), Aziza Sattarova (17873792), Jakal Amin (1936423), Svetlana V. Antonyuk (137596), Joseph P. Salisbury (1914403), Gregory A. Petsko (223381), Luke McAlary (4014524), Jeremy B. Conway (10586642), Wensheng Yang (1435912), Yunqiu Chen (1602571), Rutali R. Brahme (17873783), Nathalie Y. R. Agar (9768133), Swathi Padmakumar (17873789), Novera Alam (17873780), Jared R. Auclair (3275157), Mary Jo Ondrechen (267839), Daniel P. Donnelly (12668304), Samantha S. Watson (17873777), Jeffrey N. Agar (1862086), Aparna C. Ponmudiyan (17873795), Jenifer N. Winters (8415564), Robert H. Brown Jr. (17873807), Leigh D. Plant (4722918), S. Samar Hasnain (137599), Brandon C. Miller (10170821), Roman Manetsch (691440), David J. Greenblatt (17873804), Justin J. Yerbury (756106), Yu Xu (52257), Richa Sarin (4608202), Tanvi Gawde (17873798), Alexandra Weiss (10305144), Haneyeh Shahbazian (17873786)   +37 more
core   +1 more source

Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP-2 Signaling. [PDF]

J Med Chem
Rezzi SJ, Butticè A, Villani S, Lesca G, Rossini S, Panfili E, Mazzoletti D, Bari E, Violante D, Serafini M, Massarotti A, Orabona C, Pallotta MT, Aprile S, Fallarini S, Del Grosso E, Di Martino RMC, Miggiano R, Pirali T.   +18 more
europepmc   +1 more source