Results 191 to 200 of about 6,659,593 (302)

Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective. [PDF]

Front Immunol
Horenstein AL, Frerichs KA, Faini AC, van de Donk NWCJ, Malavasi F.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Diversity and extracellular enzymatic activity of culturable yeasts isolated from soil in a Brazilian Amazonian rainforest biome. [PDF]

Braz J Microbiol
Santos ARO, Oliveira FLC, Sander AN, Souza GFL, Barros KO, Abegg MA, Lachance MA, Rosa CA.   +7 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Assessment of microfungal contamination and enzymatic activity in ethnographic textile artifacts and museum environment. [PDF]

PLoS One
Ozdemir G, Haliki A, Çelebi M.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Insecticide Resistance Mutations, Enzymatic Activity, and Pathogen Infection in <i>Culex quinquefasciatus</i> from Haiti. [PDF]

Insects
Tanachaiwiwat P, Sanscrainte ND, Okech BA, Estep AS.   +3 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Characterization of the enzymatic activity of the rhythmic human NADP(H) phosphatase, Nocturnin. [PDF]

Arch Biochem Biophys
Olivas-Rasmussen C, Palluth L, Rasmussen ES, Green CB.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source