Results 51 to 60 of about 898,805 (244)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

In situ rheometry of concentrated cellulose fibre suspensions and relationships with enzymatic hydrolysis [PDF]

, 2013
This work combines physical and biochemical analyses to scrutinize liquefaction and saccharification of complex lignocellulose materials. A multilevel analysis (macroscopic: rheology, microscopic: particle size and morphology and molecular: sugar product)
Lombard, Eric, To, Kim Anh, Anne-Archard, Dominique, Fillaudeau, Luc, Nouhen, Arthur, Nguyen, Tien-Cuong, Coma, Véronique, Cameleyre, Xavier, Binet, Cédric   +8 more
core   +1 more source

Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands. [PDF]

PLoS ONE, 2016
BACKGROUND:A series of antioxidant enzymes and non-enzymatic compounds act to protect cells from uncontrolled propagation of free radicals. It is poorly understood, though, to what extent and how their interaction is harmonized.
María J Soto-Méndez, Concepción M Aguilera, María D Mesa, Laura Campaña-Martín, Victoria Martín-Laguna, Noel W Solomons, Klaus Schümann, Ángel Gil   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Enzymatic production of prebiotic fructo-oligosteviol glycosides

, 2022
S.79-84Fructo-oligosaccharides are low-caloric sweeteners with 30â50% of the sweetness of sucrose. They are also used as functional food ingredients due to their prebiotic properties, i.e.
Czermak, P., Spohner, S.C.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial oxidative protection by enzymatic and non-enzymatic components in cashew leaves under high salinity

, 2012
The work evaluated the role of enzymatic and non-enzymatic antioxidants in cashew (Anacardium occidentale) leaves under 0, 50, 100, 150 and 200 mM NaCl. Salt stress increased protein oxidation and decreased the lipid peroxidation, indicating that lipids ...
E. L. Voigt, J. A. G. Silveira, E. N. Silva, S. L. Ferreira-Silva, J. M. Maia, T. C. R. Aragão   +5 more
core   +1 more source

Sustainable enzymatic synthesis of glycolipids in a deep eutectic solvent system

, 2022
S.S281-S287Environmental friendly (bio-) chemical synthesis reactions are getting ever more important for the production of ecofriendly products. In this study a reaction system based on a deep eutectic solvent consisting of choline chloride and various ...
Muhle-Goll, C., Siebenhaller, S., Brenner-Weiss, G., Rupp, S., Kirschhöfer, F., Günther, Michael, Zibek, S., Hiller, Ekkehard, Luy, B., Syldatk, C.   +9 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source