Machine learning for enzyme catalytic activity: current progress and future horizons. [PDF]
Qiu S, Saeed H, Leonard W, Li F, Yang A.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Effects of High Levels of Enzyme Blend With Probiotic on Performance, Intestinal Morphology, Microbial Population, and Immune Response in Broiler Chickens. [PDF]
Esmaeili B, Afsharmanesh M, Bami MK.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Safety evaluation of the food enzyme α-amylase from the non-genetically modified <i>Aspergillus</i> sp. strain AR-SHFA-109. [PDF]
EFSA Panel on Food Enzymes (FEZ) +15 more
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Safety evaluation of a food enzyme containing cellulase, endo-1,3(4)-β-glucanase and endo-1,4-β-xylanase activities from the non-genetically modified <i>Trichoderma reesei</i> strain AR-999. [PDF]
EFSA Panel on Food Enzymes (FEZ) +18 more
europepmc +1 more source
Treatment optimization of angiotensin converting enzyme inhibitors and associated factors in Ayder Comprehensive Specialized Hospital: a cross-sectional study [PDF]
Tesfay Mehari Atey +5 more
openalex +1 more source

