Results 161 to 170 of about 6,346,353 (348)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A multimodal model for protein function prediction

Scientific Reports
Protein function, which is determined by sequence, structure, and other characteristics, plays a crucial role in an organism’s performance. Existing protein function prediction methods mainly rely on sequence data and often ignore structural properties ...
Yu Mao, WenHui Xu, Yue Shun, LongXin Chai, Lei Xue, Yong Yang, Mei Li   +6 more
doaj   +1 more source

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

Journal of Clinical Investigation, 1990
B. Rigat, C. Hubert, F. Alhenc-Gelas, F. Cambien, P. Corvol, F. Soubrier   +5 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

Circulation Research, 2000
M. Donoghue, F. Hsieh, E. Baronas, Kevin Godbout, Michael L. Gosselin, N. Stagliano, M. Donovan, Betty Woolf, K. Robison, R. Jeyaseelan, R. Breitbart, S. Acton   +11 more
semanticscholar   +1 more source

Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO³⁺, for the Carbon–Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1

, 2016
Francis K. Yoshimoto, I C Jung, Sandeep Goyal, Eric Gonzalez, F. Peter Guengerich   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.

Journal of Investigative Dermatology, 1982
P. Bradley, D. Priebat, R. Christensen, G. Rothstein   +3 more
semanticscholar   +1 more source

Enzyme replacement therapy in a feline model of Maroteaux-Lamy syndrome. [PDF]

, 1996
Allison C. Crawley, Doug A. Brooks, Vivienne Muller, B A Petersen, Elizabeth Isaac, Julie Bielicki, Barbara King, Christine D Boulter, Alison Moore, N.L. Fazzalari, D S Anson, Sharon Byers, John J. Hopwood   +12 more
openalex   +1 more source