Results 51 to 60 of about 843,424 (210)

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Beyond the whole-mount phenotype: high-resolution imaging in fluorescence-based applications on zebrafish

Biology Open, 2019
Zebrafish is now widely used in biomedical research as a model for human diseases, but the relevance of the model depends on a rigorous analysis of the phenotypes obtained.
Veronika Oralová, Joana T. Rosa, Mieke Soenens, Jan Willem Bek, Andy Willaert, Paul Eckhard Witten, Ann Huysseune   +6 more
doaj   +1 more source

Analysis of ADVIA Myeloperoxidase Cytogram LUC Angle Does Not Distinguish Acute Myeloid Leukemia From Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma in Dogs

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Acute myeloid leukemia (AML) is difficult to distinguish from lymphoblastic leukemia or lymphoma (LL) on morphologic features alone. Therapeutic approaches for AML versus LL differ, and immediate therapy is often needed due to patient illness and rapid disease progression.
Mayzie Miller, Nora L. Springer, Dorothee Bienzle, Kristina Meichner, Tracy Stokol   +4 more
wiley   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, Volume 179, Issue 3, Page 418-433, November 2026.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Localization of Epidermal Growth Factor Receptor Enhancer Protein in A431 Epidermoid Carcinoma Cells by Southwestern Histochemistry (Recent Progress In Gene Histochemistry) [PDF]

, 1998
Since abnormal expression of epidermal growth factor receptor (EGFR) is frequently associated with cancer development, the analysis of EGFR gene expression at the transcriptional level as well as the transcript level is helpful to understand the abnormal
Komuta, Ko, Koji, Takehiko, Kanematsu, Takashi, Nakane, Paul K.   +3 more
core   +1 more source

Enzyme histochemistry of uterine tube of buffalo during follicular and luteal phase: A seasonal variation

Indian Journal of Animal Sciences
Enzyme histochemistry on uterine tube of buffalo during summer and winter season was conducted in different phases of estrus cycle in relation to reproductive efficiency.
TULUMONI SEAL, ANURADHA GUPTA, VARINDER UPPAL, DEVENDRA PATHAK, NEELAM BANSAL   +4 more
doaj   +1 more source

Metabolomics Analysis Revealed That SXZ Ameliorates Cognitive Impairment in Naturally Aged Rats by Promoting Glutathione Metabolism and Inhibiting the Ferroptosis Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In aged rats, 6‐month SXZ treatment reversed spatial memory deficits and preserved hippocampal integrity. Mechanistic assays show that SXZ promotes glutathione metabolism and inhibits ferroptosis via p53/SLC7A11/GPX4 and Keap1/Nrf2/HO‐1 pathways. SXZ is a novel neuroprotective agent against age‐related cognitive decline.
Mengya Liu, Shunyi Li, Yonglin Liang, Yugui Zhang, Xutong Jia, Yongqiang Duan, Min Bai   +6 more
wiley   +1 more source

Skeletal Muscle Fibre Type Determines Mitochondrial and Metabolic Responses to Hypoxia and Pulmonary Inflammation in Young Adult Rats

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Chronic obstructive pulmonary disease (COPD) patients often experience skeletal muscle dysfunction that may result from a complex combination of mitochondrial dysfunction, metabolic reprogramming and fibre type transitions. Among other factors, pulmonary inflammation and hypoxia contribute to the COPD‐associated muscle defects ...
Angelos Gavrielatos, Cécile Cottet‐Rousselle, Noé Brocker, Cindy Tellier, Amel Achouri, Alexandre Prola, Hervé Dubouchaud, Clovis Chabert   +7 more
wiley   +1 more source

Widely Spread Butyrylcholinesterase Can Hydrolyze Acetylcholine in the Normal and Alzheimer Brain

Neurobiology of Disease, 2002
Background: Butyrylcholinesterase (BChE), also known as the “pseudo” or “non-neuronal” cholinesterase, is traditionally thought to have a restricted CNS distribution and to play little, if any, role in cholinergic transmission.
Marsel Mesulam, Angela Guillozet, Pamela Shaw, Bruce Quinn   +3 more
doaj   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source