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Studies on Antibiotics and Enzyme Inhibitors

Clinical Infectious Diseases, 1987
I have been studying antibiotics since 1944. In 1951, pathogenic bacteria resistant to antibiotic drugs had not yet appeared, and it seemed that effective chemotherapy for all bacterial diseases except tuberculosis was a fait accompli. Therefore, I initiated screening for antibiotics active against tumors.
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Angiotensin converting enzyme inhibitors

Pharmaceutisch Weekblad Scientific Edition, 1982
Inhibition of angiotensin converting enzyme (ACE) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally active ACE inhibitor and the structure-activity relationship of captopril analogues are described.
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Inhibitors of mitochondrial enzymes

Pharmacology & Therapeutics, 1979
John B. Clark, John M. Land
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Enzyme inhibitors in medicine

Natural Product Reports, 1989
C. S. J. Walpole, R. Wrigglesworth
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Enzyme inhibitors of microbial origin

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1980
The screening for enzyme inhibitors of microbial origin in the past decades has been a prosperous area to find new metabolites that are of potential importance as therapeutic or antibiotic agents. This review attempts a survey of recent achievements in this type of screening.
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Design of Enzyme Inhibitors

1996
Mechanistic insight and structural information provide the starting points for two contrasting approaches to the design of enzyme inhibitors. Phosphorus-containing peptides are inhibitors of the zinc and aspartic peptidases that mimic key geometric and electronic characteristics of the transition states of these enzymes.
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The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

Ca-A Cancer Journal for Clinicians, 2022
Sharon Elad, Noam Yarom, Yehuda Zadik
exaly  

Metal–Organic Framework-Based Enzyme Biocomposites

Chemical Reviews, 2021
, Peter Wied, Francesco Carraro
exaly  

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

Chemical Reviews, 2023
Kun-Yu Wang, Jiandong Pang, Wei Shi
exaly  

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