Results 61 to 70 of about 539,436 (357)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Pleural effusion caused by Trichinella spiralis infection: two case reports

BMC Infectious Diseases, 2023
Background Trichinosis is a worldwide food-borne zoonotic parasitic disease, which is mainly obtained by ingesting undercooked meat containing infected larvae.
Zhen-zhen Pan, Miao-juan Zhu, Yu-qiong Rong, Jiong Yang   +3 more
doaj   +1 more source

Using a solid-phase variant of enzyme immunoassay for the etiological diagnosis of endogenous uveitis

Российский офтальмологический журнал, 2023
Enzyme-linked immunosorbent assay (ELISA) has traditionally been used to diagnose infectious diseases, including ophthalmic ones. As a rule, however, investigators are only focused on differentiated detection of specific immunoglobulins (Ig) of varied ...
A. Yu. Kon’kova, E. S. Horowitz, T. V. Gavrilova, M. V. Chereshneva, E. V. Afanasievskaya   +4 more
doaj   +1 more source

Gold-black micropillar electrodes for microfluidic ELISA of bone metabolic markers [PDF]

, 2011
Modification with gold black considerably increased the detection current of protruding micropillar electrodes in microfluidic electrochemical enzyme-linked immunosorbent assay (ELISA)
Fukuda Junji, Ginoza Takahiro, Numthuam Sonthaya, Suzuki Hiroaki, Zhu Mojun, 福田 淳二, 鈴木 博章   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Epidemiological survey of Trypanosoma cruzi infection in North-Eastern Brazil using different diagnostic methods Pesquisa epidemiologica da infecção por Trypanosoma cruzi no nordeste brasileiro utilizando-se diferentes métodos diagnósticos

Revista do Instituto de Medicina Tropical de São Paulo, 1991
A survey of the prevalence of Trypanosoma cruzi infection was carried out in Oitis, a small community in the State of Piaui, Brazil. Two hundred and sixty five individuals were screened by microscopic examination, hémoculture, indirect immunofluorescence
José Figuerêdo-Silva, Yoshimasa Kaneda, Hiroshi Tachibana, Rieko Furushima, Seiki Tateno, Fernando Gomes Correia-Lima, Dalva Neves da Costa Bento   +6 more
doaj   +1 more source

Identification and validation of targets for cancer immunotherapy: from the bench-to-bedside [PDF]

, 2013
Chapter 12 in Novel Gene Therapy ...
Brooks, Suzanne E., Denniss, Frances, Guinn, Barbara-Ann, Khan, Ghazala, Sigurdardottir, Dagmar   +4 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

High-performance liquid chromatography and Enzyme-Linked Immunosorbent Assay techniques for detection and quantification of aflatoxin B1 in feed samples: a comparative study. [PDF]

, 2019
ObjectiveComparison was done between high-performance liquid chromatography (HPLC) and a competitive enzyme-linked immunosorbent assay (ELISA) for detection and quantification of aflatoxin B1 (AFB1) in feed samples.
Beyene, Achenef Melaku, Du, Xiangwei, E Schrunk, Dwayne, Ensley, Steve, Rumbeiha, Wilson K   +4 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source