Results 311 to 320 of about 2,217,916 (339)

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

Itinerant curriculum theory: People's theory against the field's epistemicidal ethos

The Curriculum Journal, EarlyView.
Abstract The field of curriculum studies suffers from a glaring theoretical impasse. Much of this impasse has been rightly attributed to the triumphalism of the neoliberal wave that has massacred the educational hemisphere with policies and practices that reduce pedagogy to an instrumentalist praxis directly associated with the thirsty desires and ...
João M. Paraskeva
wiley   +1 more source

A systematic survey of TF function in E. coli suggests RNAP stabilization is a prevalent strategy for both repressors and activators. [PDF]

Nucleic Acids Res
Guharajan S, Parisutham V, Brewster RC.
europepmc   +1 more source

Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells. [PDF]

Proc Natl Acad Sci U S A
Ferrero G, Cardamone MD, Luca F, Bourk E, Ricci L, Liu W, Gao Y, Burrone G, Muhammad A, Chan S, Smith E, Fan TC, Cutrupi S, Garcia-Bassets I, De Bortoli M, Rosenfeld MG, Perissi V.   +16 more
europepmc   +1 more source

Engineering an Overflow-Responsive Regulation System for Balancing Cellular Redox and Optimizing Microbial Production. [PDF]

Biotechnol Bioeng
Zhang J, Wang J, Jiang T, Gong X, Gan Q, Teng Y, Zou Y, Dawadi AA, Yan Y.   +8 more
europepmc   +1 more source

Design and characterization of allantoin-inducible expression systems in budding yeast. [PDF]

Biotechnol Biofuels Bioprod
Wang J, Ma J, Luo X, Wang S, Cai X, Yuan J.   +5 more
europepmc   +1 more source

Engineering intercellular communication using M13 phagemid and CRISPR-based gene regulation for multicellular computing in Escherichia coli. [PDF]

Nat Commun
Kusumawardhani H, Zoppi F, Avendaño R, Schaerli Y.   +3 more
europepmc   +1 more source

Solo or in Concert: SUMOylation in Pathogenic Fungi. [PDF]

Plant Pathol J
Lim YJ, Lee YH.
europepmc   +1 more source

Epigenetic implications in the pathogenesis of corticotroph tumors. [PDF]

Pituitary
Paes T, Hofland LJ, Iyer AM, Feelders RA.   +3 more
europepmc   +1 more source