Results 91 to 100 of about 747,478 (311)
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
A semiquantitative scoring tool to evaluate eccentric exercise-induced muscle damage in trained rats
European Journal of Histochemistry, 2015 Unaccustomed eccentric exercise is a well-documented cause of exercise-induced muscle damage. However, in trained subjects muscle injury involves only light or moderate tissue damage.
D. Rizo-Roca +7 more
doaj +1 more source
Dose-dependent new bone formation by extracorporeal shock wave application on the intact femur of rabbits [PDF]
, 2008 Background: Whereas various molecular working mechanisms of shock waves have been demonstrated, no study has assessed in detail the influence of varying energy flux densities (EFD) on new bone formation in vivo. Methods: Thirty Chinchilla bastard rabbits
Hausdorf, J. +6 more
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Influence of Lead, an Environmental Pollutant on Metamorphosis of Rana utricularia (Amphibia: Ranidae) [PDF]
, 1978 The influence of lead, an environmental pollutant on metamorphosis of Rana utricularia, was examined in this study. Larvae of stage XI (Taylor and Kollros, 1946), beginning of the premetamorphic stage, were exposed to lead concentrations of 0.1 ppm, 0.5 ...
Yeung, Gloria L.
core +2 more sources
A Model for Investigating Developmental Eye Repair in Xenopus Laevis [PDF]
, 2018 Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration.
Kha, Cindy X. +3 more
core +2 more sources
Shaping Ti3C2 MXene Nanospheres for Precision Near‐Infrared Photothermal Therapy
Advanced Functional Materials, EarlyView.In this study, we report producing spherical MXenes via fs laser fragmentation of Ti3C2 flakes in liquid medium. The nanoparticles demonstrated pronounced light absorption and high photothermal conversion efficiencies of 68% and 63% under heating with NIR‐I and NIR‐II lasers, respectively.
Julia S. Babkova +21 more
wiley +1 more source
Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study [PDF]
, 2019 BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers.
Brenner, H. +17 more
core +2 more sources
Advanced Functional Materials, EarlyView.We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li +6 more
wiley +1 more source