Results 101 to 110 of about 270,393 (395)

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

Biodegradability and tissue reaction of random copolymers of L-leucine, L-aspartic acid, and L-aspartic acid esters [PDF]

, 1977
A series of copoly(α-amino acids) with varying percentages of hydrophilic (l-aspartic acid) and hydrophobic monomers (l-leucine, ß-methyl-l-aspartate, and ß-benzyl-l-aspartate) were implanted subcutaneously in rats and the macroscopic degradation ...
Bantjes, A., Feijen, J., Marck, K.W., Sederel, W.L., Wildevuur, Ch.R.H.   +4 more
core   +3 more sources

Gold nanoparticle‐adjuvanted S protein induces a strong antigen‐specific IgG response against severe acute respiratory syndrome‐related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs

Microbiology and immunology, 2019
The spike (S) protein of coronavirus, which binds to cellular receptors and mediates membrane fusion for cell entry, is a candidate vaccine target for blocking coronavirus infection.
Hanako Sekimukai, N. Iwata-Yoshikawa, S. Fukushi, H. Tani, M. Kataoka, Tadaki Suzuki, H. Hasegawa, K. Niikura, K. Arai, N. Nagata   +9 more
semanticscholar   +1 more source

The Pathogenesis of Eosinophilic Esophagitis: Beyond the Eosinophil [PDF]

Digestive Diseases and Sciences, 2013
Over the past two decades, eosinophilic esophagitis (EoE) has undergone a remarkable transformation. What used to be a rare, case-reportable condition about which little was known, is now widely recognized as an important cause of upper GI morbidity and the subject of intense research activity.
openaire   +3 more sources

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Eosinophilic Esophagitis Is an Underlying Cause for Gastrointestinal Concerns in Children

Frontiers in Pediatrics, 2018
Eosinophilic esophagitis (EoE) is a chronic immune antigen-mediated disorder characterized by symptoms of esophageal dysfunction in combination with dense esophageal eosinophilia.
Kunsong Lee, Kunsong Lee, Glenn T. Furuta, Glenn T. Furuta, Nathalie Nguyen, Nathalie Nguyen   +5 more
doaj   +1 more source

Coral Disease and Health Workshop: Coral Histopathology II [PDF]

, 2007
The health and continued existence of coral reef ecosystems are threatened by an increasing array of environmental and anthropogenic impacts. Coral disease is one of the prominent causes of increased mortality among reefs globally, particularly in the ...
Bochsler, V. S., Galloway, S. B., Harley, R. A., Kramarsky-Winters, E., McLaughlin, S. M., Meteyer, C. U., Morado, J. F., Nicholson, J., Parnell, P. G., Peters, E. C., Reynolds, T. L., Rotstein, D. S., Sileo, L., Woodley, C. M., Work, T. M.   +14 more
core  

Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury

Advanced Science, EarlyView.
This study investigates the mechanism of succinate dehydrogenase (SDH)‐mediated succinate oxidation in microglia extracellular traps (MiETs) formation and neuronal injury after cerebra I/R injury. Dimethyl malonate (DMM), a competitive SDH inhibitor, could reduce MiETosis by inhibiting succinate oxidation and mtROS production during reperfusion ...
Lili Zhao, Tao Li, Meijuan Dang, Ye Li, Jialiang Lu, Ziwei Lu, Zhiyang Chen, Qiao Huang, Yujie Chen, Yang Yang, Yuxuan Feng, Xiaoya Wang, Yating Jian, Heying Wang, Yingying Guo, Lei Zhang, Yu Jiang, Songhua Fan, Shengxi Wu, Hong Fan, Fang Kuang, Guilian Zhang   +21 more
wiley   +1 more source

Effects of arginine and ornithine supplementation to a high‐protein diet on selected cellular immune variables in adult cats [PDF]

, 2020
Background: Dietary protein and amino acid intake and composition can modulate immune function. Objectives: To evaluate the effects of high‐protein intake and arginine and ornithine supplementation on feline immune cells.
Kohn, Barbara, Paßlack, Nadine, Zentek, Jürgen   +2 more
core   +1 more source

Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis

Nature Reviews Rheumatology, 2023
G. Emmi, A. Bettiol, E. Gelain, I. Bajema, A. Berti, S. Burns, M. Cid, J. C. Cohen Tervaert, V. Cottin, E. Durante, Julia U. Holle, A. Mahr, M. D. Del Pero, C. Marvisi, J. Mills, S. Moiseev, F. Moosig, C. Mukhtyar, T. Neumann, I. Olivotto, C. Salvarani, B. Seeliger, R. Sinico, C. Taillé, B. Terrier, N. Venhoff, G. Bertsias, L. Guillevin, D. Jayne, A. Vaglio   +29 more
semanticscholar   +1 more source