Results 301 to 310 of about 270,393 (395)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima   +5 more
wiley   +1 more source

Phenotypically distinguishable eosinophilic cells do not impact epithelial functions in a triple-culture <i>in vitro</i> intestinal model. [PDF]

open access: yesFront Immunol
Benkstein C   +13 more
europepmc   +1 more source

Exploring the Efficacy of Benralizumab in Chronic Eosinophilic Pneumonia Following Corticosteroid Therapeutic Failure: A Case Report. [PDF]

open access: yesCureus
De La O Villalobos S   +4 more
europepmc   +1 more source

Endoscopy and noninvasive tests in pediatric disorders of gut–brain interaction: A multicenter retrospective study of the Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Disorders of gut–brain interactions (DGBIs) are highly prevalent in pediatric gastroenterology and often lead to the use of invasive and noninvasive diagnostic tests, despite the guidance provided by the Rome IV criteria. Rome IV promotes a positive diagnostic approach based on the identification of specific symptoms occurring at ...
Mattia Spatuzzo   +11 more
wiley   +1 more source

Eosinophilic Myocarditis Associated With Chronic Eosinophilic Leukemia. [PDF]

open access: yesJACC Case Rep
Venkataramany BS   +4 more
europepmc   +1 more source

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