Results 191 to 200 of about 255,159 (264)

Challenges, opportunities and best practices in routine childhood vaccination services delivery in urban slums and pastoralist regions of Ethiopia: An exploratory qualitative study in marginalized settings. [PDF]

PLoS One
Gelana N, Abebe F, Tsegaw M, Tadesse Y, Kokebie MA, Gedlu T, Alemayehu H, Bikes T, Eshetu Y, Kassaye M, Endale A, Sharma R, Getachew H, Mon HS, Yadate T.   +14 more
europepmc   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Objective Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer’s disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD ...
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

Anticancer effects of alpha-helical peptide epinecidin-1 and its variants in combination with doxorubicin. [PDF]

Med Oncol
Jeyarajan S, Ranjith S, Anbarasu A, Kandasamy I, Chidambaram P, Kumarasamy A.   +5 more
europepmc   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Biochemical Profiling and Ecotoxicological Assessment of <i>Prunus spinosa</i> L. Fruits from the Cluj Region: Phytochemical Composition, Contaminant Load, and Antioxidant Potential. [PDF]

Foods
Băbălău-Fuss V, Dordai L, Roman M, Bianca S, Stroe TC, Timar AV, Becze A.   +6 more
europepmc   +1 more source

Epirubicin Alters Pancreatic Autophagy and Insulin Synthesis Through a Zinc‐Dependent Mechanism

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epirubicin (EPI) can cause metabolic side effects, including chemotherapy‐related diabetes, partly through oxidative stress that disrupts zinc (Zn) homeostasis and impairs autophagy. This study investigated the effects of EPI on Zn regulation and autophagy in the pancreas, as well as the modulatory role of N‐acetylcysteine (NAC). Rats received
Ebru Afşar, Işıl Eranıl
wiley   +1 more source

Divergent transcriptional programs and constrained metabolic states reveal selective metabolic dependencies in chemoresistant luminal breast cancer. [PDF]

Cancer Drug Resist
Poyraz M, Sari B, Ambroise J, Spears M, Michaelis M, Jindrich Cinatl Jr, Boidot R, Serafimov K, Feron O, Duhoux FP, Desgres M, Corbet C.   +11 more
europepmc   +1 more source

The Neutrophil‐To‐Lymphocyte Ratio as an Associated Biomarker of Diabetic Nephropathy in Type 2 Diabetes Mellitus

Journal of Clinical Laboratory Analysis, EarlyView.
Type 2 diabetes mellitus (T2DM) is associated with chronic low‐grade systemic inflammation. This study evaluated the neutrophil‐to‐lymphocyte ratio (NLR) as a practical inflammatory biomarker in T2DM. A cross‐sectional study was conducted in Hodeidah City among 82 participants: 42 T2DM patients and 40 healthy controls.
Yousef A. D. Alkhadem, Abdulmajeed A. A. Almaleki, Ali S. G. Alghamdi, Mohammed S. Al‐Ghamdi, Mohammed H. Mukhtar, Ali B. Al‐Zubaidy, Yahya Alsayaad   +6 more
wiley   +1 more source

Unique causes of exocrine pancreatic insufficiency: When to consider pancreatic enzyme supplementation: A narrative review. [PDF]

Nutr Clin Pract
Williams V, Funk S.
europepmc   +1 more source

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source