Results 141 to 150 of about 212,029 (313)

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Effect of oxycodone vs. morphine as first‐line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Postoperative opioids, intended for short‐term analgesia, contribute to new persistent opioid use in 1%–7% of patients, adversely affecting outcomes. Oxycodone may carry higher risk than morphine, though long‐term data are limited.
Eward J. Melis, Johanna E. Vriezekolk, Frédérique H. C. Bollen, Dirk E. Schrander, Arnt F. A. Schellekens, Bart J. F. van den Bemt   +5 more
wiley   +1 more source

Progress in epidemic-ready primary health care: early pilot results from four African countries (Ethiopia, Nigeria, Sierra Leone and Uganda), December 2023 – October 2024

BMJ Global Health
Primary healthcare (PHC) is the first point of contact with communities and essential for epidemic preparedness. The COVID-19 pandemic exposed gaps in PHC resilience.
Amanda McClelland, Tochi Okwor, Leena N Patel, Samantha Kozikott, Moreen Kamateeka, Susan Michaels-Strasser, Celestina Obiekea, Joseph Kanu, Allan Muruta, Stacey Leanne Mearns, Aisha Abba, Jenom Danjuma, Arone M Haile, Daniel Damtew, Damene Debalke, Ramatu Ngauja, Abdullah Wailagala, Atim Dansan, Amy Elizabeth Barrera-Cancedda, Justine Landegger   +19 more
doaj   +1 more source

Do consumers and healthcare professionals report the same adverse event differently? A paired analysis of duplicate vaccine safety reports in Norway

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to compare how Norwegian healthcare professionals (HCPs) and consumers reported the same adverse event (AE) following immunization with vaccines against COVID‐19 during the COVID‐19 pandemic. Specifically, we aimed to compare the extent to which HCPs and consumers reported information relevant for assessing the causal relationship ...
Tommy Emil Dzus, Johaina Sarrage, Hilde Samdal, François Montastruc, Elena Rocca   +4 more
wiley   +1 more source

Food supply chain consequences of new responses to livestock epidemics

This article studies supply chain consequences from applying the new-more socially acceptable -strategy of emergency vaccination instead of the large-scale killing of healthy animals for controlling livestock epidemics.
Meuwissen, Miranda P.M., Mourits, Monique, Bergevoet, Ron H.M., Hoste, Robert, Huirne, Ruud B.M.   +4 more
core  

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Utilization of Machine Learning Algorithms for the Strengthening of HIV Testing: A Systematic Review

Algorithms
Several machine learning (ML) techniques have demonstrated efficacy in precisely forecasting HIV risk and identifying the most eligible individuals for HIV testing in various countries. Nevertheless, there is a data gap on the utility of ML algorithms in
Musa Jaiteh, Edith Phalane, Yegnanew A. Shiferaw, Karen Alida Voet, Refilwe Nancy Phaswana-Mafuya   +4 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Individual-based closed-loop modeling of epidemics

, 2012
Conferència de la Sra. Caterina Scoglio del Deptartament d'Enginyeria Elèctrica i Computadors de la Kansas State University, dins el marc del Workshop EPINET 2012: Epidemics on Networks: Current Trends and Challenges, organitzat pel grup EDMA ...
Scoglio, Caterina
core  

Death rates from malaria epidemics, Burundi and Ethiopia.

, 2007
Death rates exceeded emergency thresholds at 4 sites during epidemics of Plasmodium falciparum malaria in Burundi (2000-2001) and in Ethiopia (2003-2004).
Legros, Dominique, Francesco Checchi, Laurence Ahoua, Balkan, S, François Dantoine, Maryline Bonnet, Tamrat, Abiy, Van Herp, M, Vincent Brown, Legros, D, Brown, Vincent, van Herp, Michel, Checchi, Francesco, Bonnet, M, Dominique Legros, Jean-Paul Guthmann, Ahoua, Laurence, Dantoine, F, Dantoine, François, Guthmann, J P, Abiy Tamrat, Bonnet, Maryline, Tamrat, A, Checchi, F, Guthmann, Jean-Paul, Brown, V, Suna Balkan, Balkan, Suna, Michel Van Herp, Ahoua, L   +29 more
core   +1 more source