Results 51 to 60 of about 232,817 (297)

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Phylodynamic analysis of HIV sub-epidemics in Mochudi, Botswana

, 2016
Southern Africa continues to be the epicenter of the HIV/AIDS epidemic. This HIV-1 subtype C epidemic has a predominantly heterosexual mode of virus transmission and high (>15%) HIV prevalence among adults.
Moyo, Sikhulile, Kühnert, Denise, Okui, Lillian, Essex, Myron, Widenfelt, Erik, Novitsky, Vladimir   +5 more
core   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Identification of genetic diversity of Bufo gargarizans and Pelophylax nigromaculatus in the three islands of Chongming insights into aquaculture resources protection

Journal of the World Aquaculture Society
Creatures grown on the island are more susceptible to genetic vulnerabilities because of their isolated nature and often limited genetic diversity. Understanding the genetic structure of these populations is crucial for effective conservation strategies,
Yiqiong Cui, Rusong Ding, Youzhong Ding, Yubo Shi, Zhenxing Su, Dian Shen, Min Chen   +6 more
doaj   +1 more source

Integrating artificial intelligence and machine learning in HIV testing interventions in Gauteng Province, South Africa: Opportunities, challenges, and implementation strategies

Southern African Journal of HIV Medicine
Background: Conventional HIV testing approaches continue to fall short of overcoming barriers to HIV testing, especially among key and priority populations at higher risk of acquiring and transmitting HIV.
Musa Jaiteh, Edith Phalane, Yegnanew A. Shiferaw, Refilwe N. Phaswana-Mafuya   +3 more
doaj   +1 more source

The Obesity Epidemic

Current Sports Medicine Reports, 2007
Introduction In June 2004, Time Magazine published a special issue titled, “America’s Obesity Crisis.” Exactly 1 year later, Scientific American, in their June 2005 issue, published an article titled, “Obesity: An Overblown Epidemic.” Was the “obesity crisis” resolved within the intervening 12-month period between these publications?
openaire   +3 more sources

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Opioid Epidemics

SSRN Electronic Journal, 2019
In this paper, I propose an economic theory that addresses the epidemic character of opioid epidemics. I consider a community in which individuals are heterogenous with respect to the experience of chronic pain and susceptibility to addiction and live through two periods.
openaire   +5 more sources

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Epidemics on weighted networks

, 2012
Conferència de la Sra. Christel Kamp del Paul-Ehrlich-Institut, dins el marc del Workshop EPINET 2012: Epidemics on Networks: Current Trends and Challenges, organitzat pel grup EDMA (Differential Equations, Modelling and Applications) de la Universitat ...
Kamp, Christel
core   +3 more sources