Results 51 to 60 of about 165,756 (267)

Tracking HIV Outcomes Among Key Populations in the Routine Health Information Management System: A Systematic Review

Sexes
Despite having the world’s largest HIV burden, South Africa has yet to attain the 95-95-95 targets. Accurate, complete, and timely data are critical for monitoring a country’s HIV progress.
Mashudu Rampilo, Edith Phalane, Refilwe Nancy Phaswana-Mafuya   +2 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Identification of genetic diversity of Bufo gargarizans and Pelophylax nigromaculatus in the three islands of Chongming insights into aquaculture resources protection

Journal of the World Aquaculture Society
Creatures grown on the island are more susceptible to genetic vulnerabilities because of their isolated nature and often limited genetic diversity. Understanding the genetic structure of these populations is crucial for effective conservation strategies,
Yiqiong Cui, Rusong Ding, Youzhong Ding, Yubo Shi, Zhenxing Su, Dian Shen, Min Chen   +6 more
doaj   +1 more source

Integrating artificial intelligence and machine learning in HIV testing interventions in Gauteng Province, South Africa: Opportunities, challenges, and implementation strategies

Southern African Journal of HIV Medicine
Background: Conventional HIV testing approaches continue to fall short of overcoming barriers to HIV testing, especially among key and priority populations at higher risk of acquiring and transmitting HIV.
Musa Jaiteh, Edith Phalane, Yegnanew A. Shiferaw, Refilwe N. Phaswana-Mafuya   +3 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Soldiers and epidemics [PDF]

Clinical Microbiology and Infection, 2012
Epidemics have accompanied wars since antiquity. They have often influenced the outcome of battles and military campaigns, and have occurred among both soldiers and civilians. Favourable conditions for their emergence result from the destruction caused by fighting, the social disorganization and collapse of health systems, the slackening of hygiene and
openaire   +2 more sources

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Evaluation of the Sexually Transmitted Infections Programme among Key and Priority Populations in Primary Healthcare Facilities to Inform a Targeted Response: A Protocol Paper

Methods and Protocols
Primary healthcare facilities lack routine diagnostic screening due to resource limitations and dependence on syndromic management, resulting in an unprecedented prevalence and incidence of sexually transmitted infections (STIs), particularly among key ...
Mohlago Ablonia Seloka, Edith Phalane, Refilwe Nancy Phaswana-Mafuya   +2 more
doaj   +1 more source

The First Outbreak of Dengue Fever in Greater Darfur, Western Sudan

Tropical Medicine and Infectious Disease, 2019
Dengue virus (DENV) is an arthropod-borne virus (arbovirus) transmitted by the Aedes mosquitoes, mainly Aedes aegypti. Dengue fever is a rapidly growing disease with expanding geographical distribution worldwide.
Ayman Ahmed, Adel Elduma, Babiker Magboul, Tarig Higazi, Yousif Ali   +4 more
doaj   +1 more source