Results 281 to 290 of about 1,195,086 (384)

Managerial Epidemiology

Journal of Primary Care & Community Health, 2013
openaire   +3 more sources

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Outbreak of equine botulism type C associated with consumption of baleage in Brazil. [PDF]

J Vet Diagn Invest
Souza LL, Lima AS, Martins AS, Silva TA, Borsanelli AC, Dutra IS, Pupin RC, Gomes DC, Lemos RA.   +8 more
europepmc   +1 more source

Epidemiological analysis of Road Accident Data Management System (RADMS) data in Tamil Nadu, India from 2011 to 2016: Future directions for an integrated national database

K. Vijay Raghavan, Sendhilkumar Muthappan, Karunya Ravi, Kathirvel Jothi, Devika Shanmugasundaram, Vettrichelvan Venkatasamy, Parasuraman Ganeshkumar, Manickam Ponnaiah   +7 more
openalex   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Surrogate Endpoints in Regulatory Decision-Making. [PDF]

Clin Transl Sci
Jeng LJB, Siegel J.
europepmc   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Correction: Evaluating the COVID-19 vaccination program in Japan, 2021 using the counterfactual reproduction number

Scientific Reports
Taishi Kayano, Yura Ko, Kanako Otani, Tetsuro Kobayashi, Motoi Suzuki, Hiroshi Nishiura   +5 more
doaj   +1 more source

Trends in diabetes and stroke-related mortality in the United States, 1999-2024: a population-based analysis. [PDF]

Ann Med Surg (Lond)
Majeed I, Kumar H, Kumar K, Bai N, Rajesh F, Kumar S, Saneha F, Aziz H, Simran F, Rani S, Suthar SS, Yusuf SA.   +11 more
europepmc   +1 more source