Results 51 to 60 of about 59,481 (265)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Prescription opioid dispensing patterns among patients with schizophrenia or bipolar disorder

BMC Psychiatry
Background Patients with schizophrenia (SZ) or bipolar disorder (BD) may have increased risk of complications from prescribed opioids, including opioid-induced respiratory depression.
Brittany D. Roy, Jianheng Li, Cathy Lally, Sarah C. Akerman, Maria A. Sullivan, James Fratantonio, William Dana Flanders, Madé Wenten   +7 more
doaj   +1 more source

Effects of physical activities on dementia‐related biomarkers: A systematic review of randomized controlled trials

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Physical activities (PA) may lead to improved cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), and dementia. The mechanisms mediating potential PA effects are unknown.
Mohammad Moniruzzaman, Aya Kadota, Maksudul Shadat Akash, Patrick J Pruitt, Katsuyuki Miura, Roger Albin, Hiroko H. Dodge   +6 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Epidemiologic, clinical and laboratory criteria and final diagnoses in PCR negative suspected Crimean-Congo hemorrhagic fever patients

Van Tıp Dergisi
INTRODUCTION: Crimean-Congo hemorrhagic fever (CCHF) disease can be confused with many diseases due to flu-like nonspecific initial symptoms and laboratory findings in endemic areas. In this study, it was aimed to evaluate the final diagnosis of patients
Ömer Karaşahin, Emine Füsun Karaşahin   +1 more
doaj   +1 more source

Epidemiologic Design Bias, Confounders, And Interaction

, 2022
Epidemiologic investigations and research studies attempt to explore the occurrence of a health event or disease within a population. This chapter provides an understanding of the different types of research bias and describes the strategies to impact ...
Porche, Demetrius J.
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Independent Relationship of Lipoprotein(a) and Carotid Atherosclerosis With Long‐Term Risk of Cardiovascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lipoprotein(a) (Lp(a)) is considered to be a causal risk factor of atherosclerotic cardiovascular disease (ASCVD), but whether there is an independent or joint association of Lp(a) and atherosclerotic plaque with ASCVD risk remains uncertain ...
Yue Qi, Youling Duan, Qiuju Deng, Na Yang, Jiayi Sun, Jiangtao Li, Piaopiao Hu, Jun Liu, Jing Liu   +8 more
doaj   +1 more source

Epidemiologic data.

, 2014
Epidemiologic data.
Christian Maihöfner (226224), Jessica Mack-Andrick (591124), Arnd Dörfler (591126), Frieder R. Lang (591125), Anne Bolwerk (591123)   +4 more
core   +1 more source