Results 81 to 90 of about 214,089 (168)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Comparing the Metagenomic Performance of Stools Collected from Custom Cards and 95% Ethanol in Epidemiologic Studies. [PDF]

Cancer Epidemiol Biomarkers Prev
Kuntz TM, Liu L, Wang K, Everett C, Eliassen AH, Willett WC, Sinha R, Chan AT, Rimm EB, Garrett WS, Segata N, Piccinno G, Huttenhower C, Morgan X, Song M.   +14 more
europepmc   +1 more source

Etiology of lung cancer: Evidence from epidemiologic studies. [PDF]

J Natl Cancer Cent, 2022
Zou K, Sun P, Huang H, Zhuo H, Qie R, Xie Y, Luo J, Li N, Li J, He J, Aschebrook-Kilfoy B, Zhang Y.   +11 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Relation of serum uric acid with the risk of coronary heart disease: an updated systematic review and dose-response meta-analysis of epidemiologic studies. [PDF]

Front Endocrinol (Lausanne)
Zhou Z, Ye G, Ren X, Cheng Y, Cang Y, Zhao J, Zhao H.   +6 more
europepmc   +1 more source

Validation of the Center for Epidemiologic Studies Depression Scale (CES-D) in a Moroccan sample with substance use disorder. [PDF]

BMC Psychiatry, 2023
El-Ammari A, El Malki H, Moutawakkil SG, El Hilaly J, El Houari F, El Gnaoui S, Ragala MEA, El Rhazi K, Zarrouq B.   +8 more
europepmc   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Metrics of Urbanicity and Rurality in US-Based Epidemiologic Studies of Ambient Temperature and Health: A Scoping Review. [PDF]

Curr Environ Health Rep
Johnson NP, Del Favero-Campbell A, Nori-Sarma A, Amezcua-Smith A, Lewis B, Chen C, Lin C, Foo D, Byun G, Choi HM, Kim H, Berman JD, Son JY, Warren JL, Chen K, Burrows K, Fong KC, Goldsmith L, Meadows MC, Smith M, Stewart R, Heo S, Lin S, Ning X, Choi Y, Bell ML, Deziel NC.   +26 more
europepmc   +1 more source

A predictive algorithm to identify ever smoking in medical claims-based epidemiologic studies. [PDF]

Ann Epidemiol, 2023
Faust I, Warden M, Camacho-Soto A, Racette BA, Searles Nielsen S.   +4 more
europepmc   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source