Results 191 to 200 of about 2,291,030 (290)

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

Advanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He   +12 more
wiley   +1 more source

Elevated hypertension risk for African-origin populations in biracial societies: modeling the Epidemiologic Transition Study. [PDF]

J Hypertens, 2015
Cooper RS, Forrester TE, Plange-Rhule J, Bovet P, Lambert EV, Dugas LR, Cargill KE, Durazo-Arvizu RA, Shoham DA, Tong L, Cao G, Luke A.   +11 more
europepmc   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

The social patterning of risk factors for noncommunicable diseases in five countries: evidence from the modeling the epidemiologic transition study (METS). [PDF]

BMC Public Health, 2016
Stringhini S, Forrester TE, Plange-Rhule J, Lambert EV, Viswanathan B, Riesen W, Korte W, Levitt N, Tong L, Dugas LR, Shoham D, Durazo-Arvizu RA, Luke A, Bovet P.   +13 more
europepmc   +1 more source

Promoting Healthier Drinking: Evidence From a Vignette Experiment on Contextual and Informational Drivers of Dealcoholized Wine Choices

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Growing demand for healthier beverages is driving innovation in the wine sector, with dealcoholized wine emerging as a promising alternative. However, little is known about the contextual conditions under which consumers would choose dealcoholized wine, particularly in countries with strong wine traditions. To fill this gap, this work examines
Giovanna Piracci, Giulia Maesano, Leonardo Casini, Maurizio Canavari, Marija Cerjak   +4 more
wiley   +1 more source

Sudden unexpected deaths in children: distinct entities. [PDF]

Eur J Pediatr
Hegyi T, Ostfeld BM.
europepmc   +1 more source

Distribution of metals exposure and associations with cardiometabolic risk factors in the "Modeling the Epidemiologic Transition Study". [PDF]

Environ Health, 2014
Ettinger AS, Bovet P, Plange-Rhule J, Forrester TE, Lambert EV, Lupoli N, Shine J, Dugas LR, Shoham D, Durazo-Arvizu RA, Cooper RS, Luke A.   +11 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Blood‐Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications

AGING MEDICINE, EarlyView.
Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley   +1 more source

A Modern Environments and Human Health. Revisiting the second epidemiologic transition

Anthropological Review, 2016
Żądzińska Elżbieta
doaj   +1 more source