Results 191 to 200 of about 1,168,053 (307)

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

Advanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go, Dahee Lee, Minji Kim, Kiseok Han, Gyuho Choi, ChanHui Song, Sanghyun Ahn, Yerim Lee, Jinyoung Lee, Yingxiao Wang, Jung‐Soo Suh, Hwayoung Yun, Tae‐Jin Kim   +12 more
wiley   +1 more source

Epidemiological risk factors for acute kidney injury outcomes in hospitalized adult patients: a multicenter cohort study. [PDF]

Clin Kidney J
Takeuchi T, Rahman AKMF, Ghazi L, Moe OW, Toto RD, Siew ED, Neyra JA, Gutierrez OM.   +7 more
europepmc   +1 more source

An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort. [PDF]

World Allergy Organ J, 2022
Lim JJ, Lim YYE, Ng JY, Malipeddi P, Ng YT, Teo WY, Wong QYA, Matta SA, Sio YY, Wong YR, Teh KF, Rawanan Shah SM, Reginald K, Say YH, Chew FT.   +14 more
europepmc   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Exploring epidemiological risk factors for cerebral amyloid angiopathy: Considerations for monoclonal antibody therapy in people with Alzheimer's disease. [PDF]

Alzheimers Dement
Ma L, Wang Y, Huynh ALH, Amadoru S, Wrigley S, Yates P, Masters CL, Goudey B, Jin L, Pan Y.   +9 more
europepmc   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Trend in the epidemiological risk of leprosy in the state of Goiás-Brazil between 2010 and 2021. [PDF]

Epidemiol Serv Saude
Barbosa CC, Barbosa CC, Guimarães RA, Vieira NF.   +3 more
europepmc   +1 more source

Evaluating Epidemiological Risk by Using Open Contact Tracing Data: Correlational Study.

J Med Internet Res, 2021
Piotto S, Di Biasi L, Marrafino F, Concilio S.   +3 more
europepmc   +1 more source

Modifiable and non-modifiable epidemiological risk factors for acne, acne severity and acne scarring among Malaysian Chinese: a cross-sectional study. [PDF]

BMC Public Health, 2021
Say YH, Heng AHS, Reginald K, Wong YR, Teh KF, Rawanan Shah SM, Sio YY, Ng YT, Matta SA, Pang SL, Chew FT.   +10 more
europepmc   +1 more source