Results 151 to 160 of about 1,221,433 (318)

Investigational Use of Real‐World Data as a Hybrid Control in Pancreatic Ductal Adenocarcinoma From the Randomized Phase Ib/II MORPHEUS Trial

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 1021-1029, April 2025.
Enrolling adequate numbers of patients into the control arm of randomized controlled trials (RCTs) often presents barriers. There is interest in leveraging real‐world data (RWD) from electronic health records (EHRs) to construct external control (EC) arms to supplement RCT control arms and form hybrid control (HC) arms.
Andrew H. Ko, Do‐Youn Oh, Janet Lau, Shivani K. Mhatre, Bo Ci, Robson Machado, Shi Li, Michael T. Bretscher, Irmarie Reyes‐Rivera, Jiawen Zhu, Xiaosong Zhang, Jilpa Patel, Matthew A. Psioda, Mariano Ponz‐Sarvise   +13 more
wiley   +1 more source

Liver diseases in Mexico and their associated mortality trends from 2000 to 2007: A retrospective study of the nation and the federal states

Annals of Hepatology, 2010
Introduction. Liver disease is a major health issue in Mexico. Although several studies have been performed to analyze the impact of liver diseases on the Mexican population, none has compared the prevalence and impact of liver disease between states ...
Nahum Méndez-Sánchez, Elsy García-Villegas, Beatriz Merino-Zeferino, Soledad Ochoa-Cruz, Antonio R. Villa, Herlinda Madrigal, Ramón A Kobashi-Margáin, Ylse Gutiérrez-Grobe, Norberto Chávez-Tapia, Guadalupe Ponciano-Rodríguez, Misael Uribe   +10 more
doaj  

Metropolitan wastewater analysis for COVID-19 epidemiological surveillance

International Journal of Hygiene and Environmental Health, 2020
W. Randazzo, E. Cuevas-Ferrando, R. Sanjuán, P. Domingo-Calap, G. Sánchez   +4 more
semanticscholar   +1 more source

POP‐REFINE: A Comprehensive Framework for Evaluating and Optimizing Representativeness in Clinical Trials

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 1051-1060, April 2025.
Clinical research has historically failed to include representative levels of historically underrepresented populations and these inequities continue to persist. Ensuring representativeness in clinical trials is crucial for patients to receive clinically appropriate treatment and have equitable access to novel therapies; enhancing the generalizability ...
Corey M. Benedum, Somnath Sarkar, Selen Bozkurt, Ruma Bhagat, Nicole Richie, Bea Lavery, Sandra D. Griffith   +6 more
wiley   +1 more source

Optimizing Global Genomic Surveillance for Early Detection of Emerging SARS-CoV-2 Variants [PDF]

arXiv
Background: Global viral threats underscore the need for effective genomic surveillance, but high costs and uneven resource distribution hamper its implementation. Targeting surveillance to international travelers in major travel hubs may offer a more efficient strategy for the early detection of SARS-CoV-2 variants.
arxiv  

Advancing Principled Pharmacoepidemiologic Research to Support Regulatory and Healthcare Decision Making: The Era of Real‐World Evidence

Clinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 927-937, April 2025.
A compilation of factors over the past decade—including the availability of increasingly large and rich healthcare datasets, advanced technologies to extract unstructured information from health records and digital sources, advancement of principled study design and analytic methods to emulate clinical trials, and frameworks to support transparent ...
Rohini K. Hernandez, Cathy W. Critchlow, Nancy Dreyer, Timothy L. Lash, Robert F. Reynolds, Henrik T. Sørensen, Jeff L. Lange, Nicolle M. Gatto, Rachel E. Sobel, Edward Chia‐Cheng Lai, Marieke Schoonen, Jeffrey S. Brown, Jennifer B. Christian, M. Alan Brookhart, Brian D. Bradbury   +14 more
wiley   +1 more source

A recent history of disease outbreaks in Kenya, 2007–2022: Findings from routine surveillance data

BMC Research Notes
Background Africa reports the highest number of outbreaks globally, accounting for 39% of all outbreaks in 2022. The Integrated Disease Surveillance and Response strategy in Kenya ensures the reporting of outbreaks up to the national level.
Farida Geteri, Jeanette Dawa, John Gachohi, Samuel Kadivane, Felix Humwa, Emmanuel Okunga   +5 more
doaj   +1 more source

HNMblock: Blockchain technology powered Healthcare Network Model for epidemiological monitoring, medical systems security, and wellness [PDF]

arXiv
In the ever-evolving healthcare sector, the widespread adoption of Internet of Things and wearable technologies facilitates remote patient monitoring. However, the existing client/server infrastructure poses significant security and privacy challenges, necessitating strict adherence to healthcare data regulations.
arxiv  

Biosafety and Genomic Epidemiological Surveillance

Epidemiology and Vaccinal Prevention
The problem of biological safety is extremely relevant today for all countries of the world because of the real and potential threats caused by biological agents that are dangerous to public health and the environment. Modern microorganisms are becoming increasingly aggressive towards humans, as clearly demonstrated by the COVID-19 pandemic, which has ...
V. G. Akimkin, T. A. Semenenko, K. F. Khafizov, S. V. Ugleva, D. V. Dubodelov, E. D. Sverdlov, A. S. Cherkashina, G. A. Gasanov, M. I. Nadtoka, N. P. Rumyantseva, Yu. V. Mikhailova, A. A. Shelenkov, A. S. Esman, I. V. Alekseenko, L. G. Kondratyeva, R. M. Beregovykh   +15 more
openaire   +2 more sources

Studies on the Stability and Microbial Biotransformation of Five Deschloroketamine Derivatives as Prerequisite for Wastewater‐Based Epidemiology Screening

Drug Testing and Analysis, EarlyView.
Microbial biotransformation and stability of deschloroketamine derivatives and their metabolites in WW by incubating parent compounds, rat urine, or rat feces showed that deschloroketamine parents and Phase I metabolite were still detectable and that Phase II metabolites decreased in peak areas.
Fabian Frankenfeld, Lea Wagmann, Markus R. Meyer   +2 more
wiley   +1 more source