Results 71 to 80 of about 381,632 (341)

Phylogenetic surveillance of viral genetic diversity and the evolving molecular epidemiology of human immunodeficiency virus type 1 [PDF]

, 2007
With ongoing generation of viral genetic diversity and increasing levels of migration, the global human immunodeficiency virus type 1 (HIV-1) epidemic is becoming increasingly heterogeneous.
, de Oliveira, Tulio, Dunn, David, Gifford, Robert J., Kellam, Paul, Pillay, Deenan, Pybus, Oliver G., Rambaut, Andrew, Vandamme, Anne-Mieke   +8 more
core   +2 more sources

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Genotypic and virulence characteristics of Listeria monocytogenes recovered from food items in Lebanon

Journal of Infection in Developing Countries, 2016
Introduction: Listeria monocytogenes is the agent of listeriosis, a life threatening foodborne disease for immunocompromised patients and pregnant women.
Nathaline Haidar-Ahmad, Kohar Annie B Kissoyan, Sukayna M Fadlallah, Rima El-Hajj, Majd Saleh, Nada Ghosn, Ghassan M Matar   +6 more
doaj   +1 more source

Ecological and epidemiological characteristics of tick-borne encephalitis in St. Petersburg

Инфекция и иммунитет, 2020
Here, we provide an analysis on 1996–2016 St. Petersburg tick-borne encephalitis (TBE) epidemiological and ecological data. In particular, two main TBE transmission vectors were observed in St. Petersburg: Ixodes persulcatus Ixodes ricinus.
E. A. Siuziumova, N. V. Telnova, A. O. Shapar, B. I. Aslanov, N. A. Stoyanova, N. K. Tokarevich   +5 more
doaj   +1 more source

Economic evaluation of the eradication program for bovine viral diarrhea in the Swiss dairy sector [PDF]

, 2017
The aim of this study was to conduct an economic evaluation of the BVD eradication program in the Swiss dairy sector. The situation before the start of the program (herd-level prevalence: 20%) served as a baseline scenario.
Häsler, B, Magouras, I, Meylan, M, Schüpbach-Regula, G, Thomann, B, Tschopp, A   +5 more
core   +2 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Effectiveness of the SARS-CoV-2 Vaccination in Preventing Severe Disease-Related Outcomes: A Population-Based Study in the Italian Province of Bolzano (South Tyrol)

International Journal of Public Health
Objective: To investigate the effectiveness of SARS-CoV2 vaccination in preventing ordinary or intensive care unit (ICU) admissions and deaths among cases registered during a variant transitional pandemic phase in the geographically and culturally unique
Antonio Lorenzon, Antonio Lorenzon, Lucia Palandri, Francesco Uguzzoni, Catalina Doina Cristofor, Filippo Lozza, Riccardo Poluzzi, Cristiana Rizzi, Pierpaolo Bertoli, Florian Zerzer, Elena Righi   +10 more
doaj   +1 more source

Predictions of the emergence of vaccine-resistant hepatitis B in The Gambia using a mathematical model [PDF]

, 2000
Vaccine escape variants of hepatitis B virus (HBV) have been identified world-wide. A mathematical model of HBV transmission is used to investigate the potential pattern of emergence of such variants.
Carman, W. (William), Nokes, D. James, Wilson, J. N.   +2 more
core   +2 more sources

Spatial And Spatio-Temporal Epidemiological Approaches To Inform Covid-19 Surveillance And Control: A Review Protocol [PDF]

, 2021
Julius Nyerere Odhiambo, Carrie B. Dolan
openalex   +1 more source