Results 41 to 50 of about 2,566,864 (251)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The Epidemiological Transition: Policy and Planning Implications for Developing Countries [PDF]

, 2010
Medical Scientists are beginning to understand better some of the trends in the changing disease and mortality patterns but policymakers need to know how to use this information to make decisions about the priorities for the health sector.
C.C Nnebue, Nnebue, C.C
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

SES Health Gradients during the Epidemiological Transition: The Case of China [PDF]

The epidemiological transition, which has already passed the developed world, is still progressing in many developing countries. A particular problem associated with this transition is the under-diagnosis and lack of treatment of chronic diseases, and ...
Yin, Nina, Zhao, Yaohui, Lei, Xiaoyan
core   +2 more sources

Necesidad de una competencia en los médicos generales básicos para la atención al adulto mayor Need for competence in basic general physicians to care for the elderly

Medisan, 2012
Se efectuó una investigación observacional analítica para caracterizar el estado actual de la atención integral al adulto mayor en la disciplina de Medicina General Integral en los policlínicos universitarios "Josué País García", "Camilo Torres Restrepo",
Reinaldo Reyes Mediaceja, Emma Aurora Bastart Ortiz, María de los Ángeles Mercaderes Ferrer, Francisco Pérez Miró, Carolina Plasencia Asorey   +4 more
doaj  

Recent trends of non-communicable diseases in Cambodia: a narrative review of challenges, risk factors, and public health strategies

Frontiers in Public Health
Non-communicable diseases (NCDs) pose a major public health issue in low- and middle-income countries (LMICs), with Cambodia facing a substantial and increasing burden.
Virak Sorn, Monirath Suon, Sin Chea
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A Bayesian inference framework to reconstruct transmission trees using epidemiological and genetic data [PDF]

, 2012
The accurate identification of the route of transmission taken by an infectious agent through a host population is critical to understanding its epidemiology and informing measures for its control. However, reconstruction of transmission routes during an
King, D.P., Soubeyrand, S., Daniel T Haydon, Marco J. Morelli (118948), Donald P. King, Morelli, Marco J., Thébaud, G., Soubeyrand, Samuel, Thébaud, Gael, Marco J. Morelli, Joël Chadœuf, Chadœuf, J., Haydon, Daniel T., King Donald P., Soubeyrand Samuel, Morelli Marco J., Donald P King, Joël Chadœuf (118955), Daniel T. Haydon, Morelli, M.J., Thébaud Gaël, Chadoeuf, Joel, Haydon, D.T., Samuel Soubeyrand (118964), Morelli , Marco J., Marco J Morelli, Donald P. King (116717), Gaël Thébaud (118951), Chadœuf Joël, King, Donald P., Daniel T. Haydon (118960), Gaël Thébaud, Haydon Daniel T., Samuel Soubeyrand   +33 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source