Results 81 to 90 of about 4,024,251 (280)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The Main Causes of Death of the Elderly in the Provinces of Iran, 2011 to 2017
Armaghane Danesh Bimonthly Journal, 2022 Background & aim: The difference in the incidence of population transition in the provinces of Iran is accompanied by differences in the indicators of aging in them.
M Torkashvand Moradabadi, M Abbasi
doaj
Development of Housing and Communal Infrastructure of the Kemerovo Region in 1946–1950
Вестник Кемеровского государственного университета, 2019 The present research features the state of housing and communal infrastructure in the Kemerovo region. The author identifies the patterns and features of its development in 1946–1950.
Zlata V. Borovikova
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Blood Pressure, 2017 A better knowledge of prevalence, management and determinants of hypertension is needed in regions in epidemiological transition to adapt the strategies of public health screening and prevention, and to reduce the burden of cardiovascular diseases.
Maxime Cournot +6 more
doaj +1 more source
No evidence for an epidemiological transition in sleep patterns among children: a 12‐country study
Sleep Health, 2018 Objective: To examine the relationships between socioeconomic status (SES; household income and parental education) and objectively measured sleep patterns (sleep duration, sleep efficiency, and bedtime) among children from around the world and explore ...
Taru Manyanga +14 more
semanticscholar +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht +53 more
wiley +1 more source
A Cross-Sectional Study on Cardiovascular Disease Risk Assessment among the Adult Population in Poonamallee Taluka, Tiruvallur District, Tamil Nadu [PDF]
HealthlineIntroduction: Non – Communicable Diseases, driven by factors like increased life expectancy, urbanization and unhealthy lifestyles have become a leading cause of morbidity and mortality worldwide.
Anjugam Sugavanam +4 more
doaj +1 more source