Results 51 to 60 of about 2,735,927 (299)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Time series regression studies in environmental epidemiology. [PDF]

, 2013
Time series regression studies have been widely used in environmental epidemiology, notably in investigating the short-term associations between exposures such as air pollution, weather variables or pollen, and health outcomes such as mortality ...
Smeeth, Liam, Bhaskaran, Krishnan, Hajat, Shakoor, Gasparrini, Antonio, Armstrong, Ben   +4 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tuberculose na população privada de liberdade do Brasil, 2007-2013

Epidemiologia e Serviços de Saúde
Resumo OBJETIVO: descrever características sociodemográficas, clínicas, e indicadores de tuberculose (TB) na população privada de liberdade (PPL) do Brasil no período 2007-2013.
Laylla Ribeiro Macedo, Ethel Leonor Noia Maciel, Claudio José Struchiner   +2 more
doaj   +1 more source

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology STROBE-ME: an extension of the STROBE statement. [PDF]

, 2011
Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change susceptibility and clinical outcomes are used as proxies for investigating the ...
David H. Phillips, Schoket, B, Peter B Farmer, Dep IRAS, G. Matullo (7601792), Vermeulen Roel, Giuseppe Matullo, Valentina Gallo, Kirsch-Volders, Micheline, B. Schoket (7601798), Porta Miquel, Kirsch-Volders, M, R. Vermeulen, Miquel Porta, Wild Christopher, Egger, M, Phillips, David, Gallo Valentina, Egger, M., Phillips, D.H., Phillips, DH, Vineis, P., Farmer, P.B., Porta, M, John P.A. Ioannidis, John P. A. Ioannidis, C. Wild, McCormack Valerie, Porta, Miquel, Porta, M., U. Stromberg (7601801), Lund University., M. Egger, Roel Vermeulen, Stromberg, U., Ioannidis, John P. A., Matullo, Giuseppe, Farmer, Peter B, P. Vineis (7601795), David H Phillips, Christopher Wild, McCormack, Valerie, Schoket Bernadette, B. Schoket, Farmer, PB, John P A Ioannidis, G. Matullo, Stromberg, U, Ioannidis, JP, Wild, C., Farmer, Peter B., Ulf Stromberg, Valerie McCormack, Matullo Giuseppe, V. Gallo (7601771), Vineis, Paolo, Loannidis, John P. A., D. H. Phillips (2298805), Gallo, Valentina, V. Mccormack (7601777), Wild, Christopher, V. Gallo, U. Stromberg, STROBE Statement, J. P. A. Ioannidis (7601786), M. Egger (7601774), P. B. Farmer, Matthias Egger, C. Wild (7601780), Schoket, B., V. McCormack, Strömberg, Ulf,, Gallo, V., P. Vineis, Gallo, V, Phillips, David H., Peter B. Farmer, Wild, C, Kirsch-Volders, M., R. Vermeulen (3788842), Phillips, David H, ?, ?, Stromberg, Ulf, McCormack, V., Phillips David H., M. Porta (7601804), Farmer Peter B., Ioannidis John P. A., M. Kirsch-Volders, Bernadette Schoket, Egger, Matthias, Egger Matthias, Ioannidis, John P A, McCormack, V, Vermeulen, Roel, Risk Assessment of Toxic and Immunomodulatory Agents, D. H. Phillips, Ioannidis, J.P., M. Porta, Matullo, G, Stromberg Ulf, Vineis Paolo, Vermeulen, R., Ioannidis, John PA, J. P. A. Ioannidis, M. Kirsch-Volders (7601789), Schoket, Bernadette, Matullo, G., P. B. Farmer (7601783), Vineis, P, STROBE Statement,, Kirsch-Volders Micheline, Micheline Kirsch-Volders, Porta, Miguel, Paolo Vineis, Vermeulen, R, Micheline Volders   +116 more
core   +9 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

GESTATIONAL SYPHILIS IN SANTA CATARINA: TEMPORAL ANALYSIS BY MACRO-REGION BETWEEN 2013 AND 2023

Brazilian Journal of Infectious Diseases
Introduction: Syphilis is a systemic infection caused by Treponema pallidum, with a high degree of pathogenicity, which can be transmitted vertically during pregnancy and lead to unfavorable outcomes for mother and baby.
Maura Jacqueline Vizentim, Julia de Simas, Maria Eduarda Cariolato Grasel, Ana Carolina Goulart, Amábile Hillesheim Scharf, Daniela Quedi Willig, Clarissa Niero Moraes   +6 more
doaj   +1 more source

A descriptive epidemiology of screen-based devices by children and adolescents : a scoping review of 130 surveillance studies since 2000 [PDF]

, 2020
Excessive use of screen-based devices can be detrimental for child and adolescent health. While epidemiological reviews have been focusing on traditional screen-based activities (e.g., television, computer use), the availability of newer screen-based ...
Jason A. Bennie, George Thomas, Katrien De Cocker, Biddle, Stuart J. H., De Cocker, Katrien, Castro, Oscar, Stuart J. H. Biddle, Thomas, George, Biddle, Stuart, Bennie, Jason A., Oscar Castro, Bennie, Jason   +11 more
core   +1 more source