Results 121 to 130 of about 1,303,488 (267)

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Persistent poverty and late-stage breast cancer diagnosis in the United States: Impacts of rural residence, race, and time within Surveillance Epidemiology and End Results registries, 2004 to 2021 [PDF]

Heather R. Sherr, Amr S. Soliman, Kimberly A. Bertrand, Kelly A. Hirko   +3 more
openalex   +1 more source

Descriptive spatial epidemiology of subclinicalSalmonellainfection in finisher pig herds: application of a novel method of spatially adaptive smoothing [PDF]

, 2007
Jackie Benschop, Martin L. Hazelton, Mark A. Stevenson, Jan Dahl, ROGER S. MORRIS, Nigel French   +5 more
openalex   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

Modeling the Influences of Climate Conditions on Measles Transmission in China - ERRATUM. [PDF]

Epidemiol Infect
Wang P, Chen J, Zhang W, Wang Y, Yang W.
europepmc   +1 more source

Epidemiology and Pathogenesis of Pediatric Respiratory Infections: A Comprehensive Review [PDF]

Linfei Ren, Wang Tingting, Jing Wang, T. La, Li Xiaocong, Xiao Weili, Ding Haitao   +6 more
openalex   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Critical mapping of epidemiology training in graduate programs in collective health in Brazil: challenges and perspectives. [PDF]

Rev Bras Epidemiol
Muraro AP, Souza AM, Buchalla CM, Melo ECP, Gibson G, Silva JATÁD, Maia LTS, Figueiredo MAA, Peixoto SV, Simões TC, Hattori WT, Araújo TM.   +11 more
europepmc   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

A Call for an Inclusive Path Forward: Developing a Roadmap for Diversity and Equity for Field Epidemiologists. [PDF]

Public Health Chall
Hammersley-Mather R, Housen T, Palmieri S, Field E.   +3 more
europepmc   +1 more source